Cellular senescence entails a permanent proliferative arrest, coupled to multiple phenotypic
changes. Among these changes is the release of numerous biologically active molecules …

Calcium ion (Ca 2+) is a ubiquitous and versatile signaling molecule controlling a wide
variety of cellular processes, such as proliferation, cell death, migration, and immune …

Despite clinical and scientific advancements, heart failure is the major cause of morbidity
and mortality worldwide. Both mitochondrial dysfunction and inflammation contribute to the …

Mitochondrial dysfunction is linked to age-associated inflammation or inflammaging, but
underlying mechanisms are not understood. Analyses of 700 human blood transcriptomes …

Non-alcoholic fatty liver disease (NAFLD) is caused by imbalance in lipid metabolism. In this
study, we show that the hepatokine orosomucoid (ORM) 2 is a key regulator of de novo …

Cellular senescence represents an irreversible state of cell-cycle arrest during which cells
secrete senescence-associated secretory phenotypes, including inflammatory factors and …

Cellular senescence is a state of stable cell proliferation arrest accompanied by a distinct
secretory program impacting the senescent cell microenvironment. This phenotype can be …

Multiple forms of regulated cell death (RCD) have been characterized, each of which
originates from the activation of a dedicated molecular machinery. RCD can occur in purely …

A key aim in epidemiological neuroscience is identification of markers to assess brain health
and monitor therapeutic interventions. Quantitative susceptibility map** (QSM) is an …

Mitochondria-endoplasmic reticulum (ER) contact sites (MERCS) are morpho-functional
units, formed at the loci of close apposition of the ER-forming endomembrane and outer …