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Microtubules and microtubule-associated proteins
Microtubules act as “railways” for motor-driven intracellular transport, interact with accessory
proteins to assemble into larger structures such as the mitotic spindle, and provide an …
proteins to assemble into larger structures such as the mitotic spindle, and provide an …
[HTML][HTML] The cytoskeleton—a complex interacting meshwork
T Hohmann, F Dehghani - Cells, 2019 - mdpi.com
The cytoskeleton of animal cells is one of the most complicated and functionally versatile
structures, involved in processes such as endocytosis, cell division, intra-cellular transport …
structures, involved in processes such as endocytosis, cell division, intra-cellular transport …
Building the neuronal microtubule cytoskeleton
Microtubules are one of the major cytoskeletal components of neurons, essential for many
fundamental cellular and developmental processes, such as neuronal migration, polarity …
fundamental cellular and developmental processes, such as neuronal migration, polarity …
Recent progress on tubulin inhibitors with dual targeting capabilities for cancer therapy
W Shuai, G Wang, Y Zhang, F Bu, S Zhang… - Journal of medicinal …, 2021 - ACS Publications
Microtubules play a crucial role in multiple cellular functions including mitosis, cell signaling,
and organelle trafficking, which makes the microtubule an important target for cancer …
and organelle trafficking, which makes the microtubule an important target for cancer …
Microtubule nucleation: beyond the template
Microtubules are cytoskeletal filaments central to a wide range of essential cellular functions
in eukaryotic cells. Consequently, cells need to exert tight control over when, where and how …
in eukaryotic cells. Consequently, cells need to exert tight control over when, where and how …
Non-equilibrium assembly of microtubules: from molecules to autonomous chemical robots
Biological systems have evolved to harness non-equilibrium processes from the molecular
to the macro scale. It is currently a grand challenge of chemistry, materials science, and …
to the macro scale. It is currently a grand challenge of chemistry, materials science, and …
Microtubule-severing enzymes: From cellular functions to molecular mechanism
Microtubule severing was first reported in Xenopus laevis egg extracts (Vale, 1991). The first
microtubule-severing enzyme was purified from sea urchin eggs (McNally and Vale, 1993) …
microtubule-severing enzyme was purified from sea urchin eggs (McNally and Vale, 1993) …
[HTML][HTML] Microtubule minus-end stabilization by polymerization-driven CAMSAP deposition
Microtubules are cytoskeletal polymers with two structurally and functionally distinct ends,
the plus-and the minus-end. Here, we focus on the mechanisms underlying the regulation of …
the plus-and the minus-end. Here, we focus on the mechanisms underlying the regulation of …
Protein rescue from aggregates by powerful molecular chaperone machines
SM Doyle, O Genest, S Wickner - Nature reviews Molecular cell biology, 2013 - nature.com
Protein quality control within the cell requires the interplay of many molecular chaperones
and proteases. When this quality control system is disrupted, polypeptides follow pathways …
and proteases. When this quality control system is disrupted, polypeptides follow pathways …
Microtubule minus-end-targeting proteins
Microtubules are cytoskeletal filaments that are intrinsically polarized, with two structurally
and functionally distinct ends, the plus end and the minus end. Over the last decade …
and functionally distinct ends, the plus end and the minus end. Over the last decade …