The anticancer properties of harmine and its derivatives

AA Timbilla, R Vrabec, R Havelek, M Rezacova… - Phytochemistry …, 2024 - Springer
This review aims to provide information about the anticancer potential of harmine, a β-
carboline alkaloid that was initially isolated in 1847 from the seeds and roots of Peganum …

Unveiling the potential of HS-1793: a review of its anticancer properties and therapeutic promise

X Capó, M Jiménez-Garcia, F Sharopov… - Future Medicinal …, 2024 - Taylor & Francis
ABSTRACT HS-1793 is a novel derivative of resveratrol, a compound known for its
numerous beneficial effects, including anticancer activity, anti-inflammatory response …

[HTML][HTML] Unveiling the antiglioblastoma potential of harmicens, harmine and ferrocene hybrids

G Poje, D Šakić, M Marinović, J You, M Tarpley… - Acta …, 2024 - hrcak.srce.hr
Sažetak The poor prognosis of glioblastoma multiforme, inadequate treatment options, and
growing drug resistance urge the need to find new effective agents. Due to the significant …

[HTML][HTML] 3-Tetrazolyl-β-carboline derivatives as potential neuroprotective agents

JLP Ribeiro, I Costa, R Silva, SMM Lopes… - Bioorganic & Medicinal …, 2024 - Elsevier
Tetrazolyl-β-carbolines were prepared by the Pictet-Spengler approach using a tryptophan
analogue as building block, in which the carboxylic acid was replaced by the bioisosteric …

Design and optimization of novel Tetrahydro-β-carboline-based HDAC inhibitors with potent activities against tumor cell growth and metastasis

S Fan, Z Wan, Y Qu, W Lu, X Li, F Yang… - Bioorganic & Medicinal …, 2024 - Elsevier
Histone deacetylases (HDACs) are validated drug targets for various therapeutic
applications. A series of Tetrahydro-β-carboline-based hydroxamate derivatives, designed …

Synthesis, pharmacological evaluation, and modeling of novel quaternary ammonium salts derived from β-carboline containing an imidazole moiety as angiogenesis …

S Chen, X Chen, D Qiu, J Wei, J Zhang… - Bioorganic & Medicinal …, 2024 - Elsevier
In this study, a series of novel β-carboline condensed imidazolium derivatives (7a-7y) were
designed and synthesized by incorporating imidazolium salt structures into β-carboline. The …

Comparative Metabolite Profiling of Three Savannic Species of Banisteriopsis (Malpighiaceae) via UPLC‐MS/MS and Chemometric Tools

JMG da Silva, RF de Almeida… - Chemistry & …, 2024 - Wiley Online Library
Banisteriopsis (Malpighiaceae) is an important genus of neotropical savannas with related
biological and medicinal activities but under‐explored metabolomic profiles. We present a …

Transition Metal‐Free Synthesis of β‐Carboline Substituted 1, 2, 3‐Thiadiazoloyl Derivatives Using Elemental Sulfur as a Sulfur Source

D Deepika, V Singh, A Bansal… - Asian Journal of Organic … - Wiley Online Library
A transition metal‐free, I2‐catalyzed C‐S cross‐coupling reaction has been developed for
the synthesis of β‐carboline substituted 1, 2, 3‐thiadiazoloyl derivatives using β‐carboline …

Network Pharmacology Analysis of Secondary Metabolites of Ciplukan (Physalis angulata L.) Against Lung Cancer

A Khoirunnisa, AS Jamil, MA Muchlisin - Majalah Farmaseutik - journal.ugm.ac.id
Lung cancer is the most common and high-risk type of cancer. Ciplukan (Physalis angulata
L.) has antibacterial, anti-inflammatory, and anticancer activities, as well as cytotoxic ability …

[PDF][PDF] NGHIÊN CỨU CÁC CHẤT XÚC TÁC CHO PHẢN ỨNG GHÉP NỐI CN ĐỂ TỔNG HỢP CÁC HỢP CHẤT DỊ VÒNG PYRIDOIMIDAZOINDOLE, CARBAZOLE VÀ …

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