Per-and polyfluoroalkyl substances (PFAS) have become internationally recognized over
the past three decades as persistent organic pollutants used in the production of various …

Background Polyploidization, a process where cells acquire additional chromosome sets, is
a unique characteristic of hepatocytes. This process has been increasingly recognized as an …

Background: Traditional toxicity testing emphasizes animal models with growing concerns
regarding predictive capacity, throughput and ethics. Rapid innovation surrounding human …

Objective: Drug-induced liver injury (DILI) is the leading cause of acute liver failure and
poses a significant challenge to human health. Rhubarb (Rheum officinale Baill. DaHuang) …

The liver is the primary organ responsible for the detoxification and metabolism of drugs. To
date, a lack of preclinical models that accurately emulate drug metabolism by the human …

The liver has excellent regeneration potential and attains complete functional recovery from
partial hepatectomy. The regenerative mechanisms malfunction in chronic liver diseases …

Animal studies are typically utilized to understand the complex mechanisms associated with
toxicant-induced hepatotoxicity. Among the alternative approaches to animal studies, in vitro …

Cardiotoxicity associated with hepatic metabolism and drug–drug interactions is a serious
concern. Predicting drug toxicity using animals remains challenging due to species and …

To investigate the impact of the ethanoic fractions of Periploca forrestii Schltr.(P. forrestii) in
ameliorating the liver injury caused by fluoride ingestion and to explore the potential …

In the early stages of liver carcinogenesis, rare hepatocytes and cholangiocytes are
transformed into preneoplastic cells, which can progressively acquire a neoplastic …