What is a transcriptional burst?
E Tunnacliffe, JR Chubb - Trends in Genetics, 2020 - cell.com
The idea that gene activity can be discontinuous will not surprise many biologists–many
genes are restricted in when and where they can be expressed. Yet during the past 15 …
genes are restricted in when and where they can be expressed. Yet during the past 15 …
Eukaryotic transcriptional dynamics: from single molecules to cell populations
Transcriptional regulation is achieved through combinatorial interactions between regulatory
elements in the human genome and a vast range of factors that modulate the recruitment …
elements in the human genome and a vast range of factors that modulate the recruitment …
SINCERITIES: inferring gene regulatory networks from time-stamped single cell transcriptional expression profiles
Motivation Single cell transcriptional profiling opens up a new avenue in studying the
functional role of cell-to-cell variability in physiological processes. The analysis of single cell …
functional role of cell-to-cell variability in physiological processes. The analysis of single cell …
Behavior genetics and postgenomics
E Charney - Behavioral and brain sciences, 2012 - cambridge.org
The science of genetics is undergoing a paradigm shift. Recent discoveries, including the
activity of retrotransposons, the extent of copy number variations, somatic and chromosomal …
activity of retrotransposons, the extent of copy number variations, somatic and chromosomal …
Bounded Synchronization and State Estimation for Discrete Time-Varying Stochastic Complex Networks Over a Finite Horizon
In this paper, new synchronization and state estimation problems are considered for an
array of coupled discrete time-varying stochastic complex networks over a finite horizon. A …
array of coupled discrete time-varying stochastic complex networks over a finite horizon. A …
Discrete distributional differential expression (D3E) - a tool for gene expression analysis of single-cell RNA-seq data
M Delmans, M Hemberg - BMC bioinformatics, 2016 - Springer
Background The advent of high throughput RNA-seq at the single-cell level has opened up
new opportunities to elucidate the heterogeneity of gene expression. One of the most …
new opportunities to elucidate the heterogeneity of gene expression. One of the most …
Noise and the molecular processes underlying cell fate decision-making
Cell fate decision-making events involve the interplay of many molecular processes, ranging
from signal transduction to genetic regulation, as well as a set of molecular and …
from signal transduction to genetic regulation, as well as a set of molecular and …
Inferring gene regulatory networks from single-cell data: a mechanistic approach
Background The recent development of single-cell transcriptomics has enabled gene
expression to be measured in individual cells instead of being population-averaged. Despite …
expression to be measured in individual cells instead of being population-averaged. Despite …
Exactly solvable models of stochastic gene expression
Stochastic models are key to understanding the intricate dynamics of gene expression.
However, the simplest models that only account for active and inactive states of a gene fail to …
However, the simplest models that only account for active and inactive states of a gene fail to …
What do expression dynamics tell us about the mechanism of transcription?
DR Larson - Current opinion in genetics & development, 2011 - Elsevier
Single-cell microscopy studies have the potential to provide an unprecedented view of gene
expression with exquisite spatial and temporal sensitivity. However, there is a challenge to …
expression with exquisite spatial and temporal sensitivity. However, there is a challenge to …