Sex and gender differences in myocarditis and dilated cardiomyopathy: An update

DL Fairweather, DJ Beetler, N Musigk… - Frontiers in …, 2023 - frontiersin.org
In the past decade there has been a growing interest in understanding sex and gender
differences in myocarditis and dilated cardiomyopathy (DCM), and the purpose of this review …

Mechanistic pathways of sex differences in cardiovascular disease

V Regitz-Zagrosek, G Kararigas - Physiological reviews, 2017 - journals.physiology.org
Major differences between men and women exist in epidemiology, manifestation,
pathophysiology, treatment, and outcome of cardiovascular diseases (CVD), such as …

Sex differences in myocardial and vascular aging

H Ji, AC Kwan, MT Chen, D Ouyang… - Circulation …, 2022 - ahajournals.org
It is well known that cardiovascular disease manifests differently in women and men. The
underlying causes of these differences during the aging lifespan are less well understood …

Estrogen-related mechanisms in sex differences of hypertension and target organ damage

AR Sabbatini, G Kararigas - Biology of sex differences, 2020 - Springer
Hypertension (HTN) is a primary risk factor for cardiovascular (CV) events, target organ
damage (TOD), premature death and disability worldwide. The pathophysiology of HTN is …

Menopause-Related Estrogen Decrease and the Pathogenesis of HFpEF: JACC Review Topic of the Week

AR Sabbatini, G Kararigas - Journal of the American College of Cardiology, 2020 - jacc.org
Heart failure (HF) is a complex condition affecting> 40 million people worldwide. It is defined
by failure of the heart to pump (HF with reduced ejection fraction) or by the failure of the …

Sex in basic research: concepts in the cardiovascular field

R Ventura-Clapier, E Dworatzek… - Cardiovascular …, 2017 - academic.oup.com
Women and men, female and male animals and cells are biologically different, and
acknowledgement of this fact is critical to advancing medicine. However, incorporating …

Decellularized tissues as platforms for in vitro modeling of healthy and diseased tissues

MW McCrary, D Bousalis, S Mobini, YH Song… - Acta biomaterialia, 2020 - Elsevier
Biomedical engineers are at the forefront of develo** novel treatments to improve human
health, however, many products fail to translate to clinical implementation. In vivo pre-clinical …

Widespread sex dimorphism in aging and age-related diseases

NK Sampathkumar, JI Bravo, Y Chen, PS Danthi… - Human genetics, 2020 - Springer
Although aging is a conserved phenomenon across evolutionary distant species, aspects of
the aging process have been found to differ between males and females of the same …

Matters of the heart: Cellular sex differences

CJ Walker, ME Schroeder, BA Aguado… - Journal of molecular and …, 2021 - Elsevier
Nearly all cardiovascular diseases show sexual dimorphisms in prevalence, presentation,
and outcomes. Until recently, most clinical trials were carried out in males, and many animal …

A framework for develo** sex-specific engineered heart models

R Lock, H Al Asafen, S Fleischer, M Tamargo… - Nature Reviews …, 2022 - nature.com
The convergence of tissue engineering and patient-specific stem cell biology has enabled
the engineering of in vitro tissue models that allow the study of patient-tailored treatment …