Osteoporosis is a common skeletal disease, affecting~ 200 million people around the world.
As a complex disease, osteoporosis is influenced by many factors, including diet (eg calcium …

Mesenchymal stem cell (MSC) therapies have been used as cell-based treatments for
decades, owing to their anti-inflammatory, immunomodulatory, and regenerative properties …

Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide
association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and …

Objective There is considerable evidence for relationship between gut microbiota and
osteoarthritis (OA), but no studies have investigated their causal relationship. Method This …

Research into the molecular genetics of osteoarthritis (OA) has been substantially bolstered
in the past few years by the implementation of powerful genome-wide scans that have …

Stem cell senescence is characterized by progressive functional dysfunction and secretory
phenotypic changes including decreased proliferation, dysfunction of osteogenic and …

Hip fracture is the clinically most important fracture, but the genetic architecture of hip
fracture is unclear. Here, we perform a large-scale hip fracture genome-wide association …

Although osteoarthritis (OA) aetiology is complex, genetic, genomic and epigenetic studies
published within the last decade have advanced our understanding of the molecular …

Molecular understanding of osteoarthritis (OA) has greatly increased over the past 15 years
through careful analysis of tissue samples, pre-clinical models and large-scale agnostic '∼ …

Osteoarthritis is a common progressive joint disease. As no effective medical interventions
are available, osteoarthritis often progresses to the end stage, in which only surgical options …