Advances of reverse vaccinology for mRNA vaccine design against SARS-CoV-2: a review of methods and tools
mRNA vaccines are a new class of vaccine that can induce potent and specific immune
responses against various pathogens. However, the design of mRNA vaccines requires the …
responses against various pathogens. However, the design of mRNA vaccines requires the …
Revisiting the dimensions of universal vaccine with special focus on COVID-19: Efficacy versus methods of designing
P Jaishwal, K Jha, SP Singh - International Journal of Biological …, 2024 - Elsevier
Even though the use of SARS-CoV-2 vaccines during the COVID-19 pandemic showed
unprecedented success in a short time, it also exposed a flaw in the current vaccine design …
unprecedented success in a short time, it also exposed a flaw in the current vaccine design …
Investigation of the MDM2-binding potential of de novo designed peptides using enhanced sampling simulations
The tumor suppressor p53 plays a crucial role in cellular responses to various stresses,
regulating key processes such as apoptosis, senescence, and DNA repair. Dysfunctional …
regulating key processes such as apoptosis, senescence, and DNA repair. Dysfunctional …
MasitinibL shows promise as a drug-like analog of masitinib that elicits comparable SARS-Cov-2 3CLpro inhibition with low kinase preference
SARS-CoV-2 infection has led to several million deaths worldwide and ravaged the
economies of many countries. Hence, develo** therapeutics against SARS-CoV-2 …
economies of many countries. Hence, develo** therapeutics against SARS-CoV-2 …
Delineation of the CENP-LN sub-complex dissociation mechanism upon multisite phosphorylation during mitosis
OA Durojaye - Journal of Biomolecular Structure and Dynamics, 2024 - Taylor & Francis
Phosphorylation is the most prevalent form of regulation in cells, organizing virtually all
cellular functions, including survival, motility, differentiation, proliferation, and metabolism …
cellular functions, including survival, motility, differentiation, proliferation, and metabolism …
The advantage of using immunoinformatic tools on vaccine design and development for coronavirus
J García-Machorro, GL Ramírez-Salinas… - Vaccines, 2022 - mdpi.com
After the outbreak of SARS-CoV-2 by the end of 2019, the vaccine development strategies
became a worldwide priority. Furthermore, the appearances of novel SARS-CoV-2 variants …
became a worldwide priority. Furthermore, the appearances of novel SARS-CoV-2 variants …
Computer-aided molecular modeling and structural analysis of the human centromere protein–HIKM complex
Background Protein–peptide and protein–protein interactions play an essential role in
different functional and structural cellular organizational aspects. While Cryo-EM and X-ray …
different functional and structural cellular organizational aspects. While Cryo-EM and X-ray …
Design of multi-epitope-based therapeutic vaccine candidates from HBc and HBx proteins of hepatitis B virus using reverse vaccinology and immunoinformatics …
The major problem in cases of chronic hepatitis B (CHB) is the failure of the patient's
immune response to eliminate the covalently closed circular DNA (cccDNA) …
immune response to eliminate the covalently closed circular DNA (cccDNA) …
Immunology to Immunotherapeutics of SARS-CoV-2: Identification of Immunogenic Epitopes for Vaccine Development
The emergence of COVID19 pandemic caused by SARS-CoV-2 virus has created a global
public health and socio-economic crisis. Immunoinformatics-based approaches to …
public health and socio-economic crisis. Immunoinformatics-based approaches to …
Design of a Multiepitope Pan‐Proteomic mRNA Vaccine Construct Against African Swine Fever Virus: A Reverse Vaccinology Approach
African swine fever (ASF), caused by African swine fever virus (ASFV), is a highly contagious
disease with devastating effects on the global pig industry. This warrants the development of …
disease with devastating effects on the global pig industry. This warrants the development of …