Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms

E Elinav, R Nowarski, CA Thaiss, B Hu, C **… - Nature Reviews …, 2013 - nature.com
Inflammation is a fundamental innate immune response to perturbed tissue homeostasis.
Chronic inflammatory processes affect all stages of tumour development as well as therapy …

Inflammation and colon cancer

J Terzić, S Grivennikov, E Karin, M Karin - Gastroenterology, 2010 - Elsevier
The connection between inflammation and tumorigenesis is well-established and in the last
decade has received a great deal of supporting evidence from genetic, pharmacological …

Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage

SI Grivennikov, M Karin - Annals of the rheumatic diseases, 2011 - ard.bmj.com
Up to 20% of all cancers arise in association with chronic inflammation and most, if not all,
solid tumours contain inflammatory infiltrates. Immune cells have a broad impact on tumour …

TLR-signaling and proinflammatory cytokines as drivers of tumorigenesis

KV Korneev, KSN Atretkhany, MS Drutskaya… - Cytokine, 2017 - Elsevier
The link between inflammation and cancer was first proposed by R. Virchow. It was later
realized that it is chronic inflammation that may promote cancer, whereas acute inflammation …

Inflammation and oncogenesis: a vicious connection

SI Grivennikov, M Karin - Current opinion in genetics & development, 2010 - Elsevier
Epidemiological and experimental data suggest a close connection between inflammation
and tumorigenesis. Solid tumors are typically infiltrated with immune cells and inflammation …

TNF-α downregulates inhibitory neurotransmission through protein phosphatase 1-dependent trafficking of GABAA receptors

H Pribiag, D Stellwagen - Journal of Neuroscience, 2013 - Soc Neuroscience
Inflammation has been implicated in the progression of neurological disease, yet precisely
how inflammation affects neuronal function remains unclear. Tumor necrosis factor-α (TNFα) …

Transcriptional control of the TNF gene

JV Falvo, AV Tsytsykova, AE Goldfeld - TNF Pathophysiology, 2010 - karger.com
The cytokine TNF is a critical mediator of immune and inflammatory responses. The TNF
gene is an immediate early gene, rapidly transcribed in a variety of cell types following …

T and B cells participate in bone repair by infiltrating the fracture callus in a two-wave fashion

I Könnecke, A Serra, T El Khassawna, C Schlundt… - Bone, 2014 - Elsevier
Fracture healing is a regenerative process in which bone is restored without scar tissue
formation. The healing cascade initiates with a cycle of inflammation, cell migration …

Anti-inflammatory functions of glucocorticoid-induced genes

AR Clark - Molecular and cellular endocrinology, 2007 - Elsevier
There is a broad consensus that glucocorticoids (GCs) exert anti-inflammatory effects largely
by inhibiting the function of nuclear factor κB (NFκB) and consequently the transcription of …

Role of inflammation in diabetic nephropathy

O Lenz, A Fornoni, A Ijaz, T Tejada - Current diabetes reviews, 2008 - ingentaconnect.com
Diabetic nephropathy (DN) is the leading cause of end stage renal disease (ESRD).
Although the pathogenesis of DN is multifactorial, local inflammatory stress may result from …