Apoptotic cell death in disease—Current understanding of the NCCD 2023
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …
[HTML][HTML] Tumor suppressor p53: Biology, signaling pathways, and therapeutic targeting
LJH Borrero, WS El-Deiry - Biochimica et Biophysica Acta (BBA)-Reviews …, 2021 - Elsevier
TP53 is the most commonly mutated gene in human cancer with over 100,000 literature
citations in PubMed. This is a heavily studied pathway in cancer biology and oncology with a …
citations in PubMed. This is a heavily studied pathway in cancer biology and oncology with a …
How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?
The tumour suppressor gene TP53 is mutated in~ 50% of human cancers. In addition to its
function in tumour suppression, p53 also plays a major role in the response of malignant as …
function in tumour suppression, p53 also plays a major role in the response of malignant as …
BCL-2 protein family: attractive targets for cancer therapy
Acquired resistance to cell death is a hallmark of cancer. The BCL-2 protein family members
play important roles in controlling apoptotic cell death. Abnormal over-expression of pro …
play important roles in controlling apoptotic cell death. Abnormal over-expression of pro …
Should mutant TP53 be targeted for cancer therapy?
Z Wang, A Strasser, GL Kelly - Cell Death & Differentiation, 2022 - nature.com
Mutations in the TP53 tumour suppressor gene are found in~ 50% of human cancers [,,,,–].
TP53 functions as a transcription factor that directly regulates the expression of~ 500 genes …
TP53 functions as a transcription factor that directly regulates the expression of~ 500 genes …
The ARTS of p53-dependent mitochondrial apoptosis
The tumor-suppressive activity of p53 is largely attributed to its ability to induce cell death,
including apoptosis, through transcription-dependent and transcription-independent …
including apoptosis, through transcription-dependent and transcription-independent …
The cell-cycle arrest and apoptotic functions of p53 in tumor initiation and progression
J Chen - Cold Spring Harbor perspectives in …, 2016 - perspectivesinmedicine.cshlp.org
P53 is a transcription factor highly inducible by many stress signals such as DNA damage,
oncogene activation, and nutrient deprivation. Cell-cycle arrest and apoptosis are the most …
oncogene activation, and nutrient deprivation. Cell-cycle arrest and apoptosis are the most …
Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies
The'hallmarks of cancer'are generally accepted as a set of genetic and epigenetic
alterations that a normal cell must accrue to transform into a fully malignant cancer. It follows …
alterations that a normal cell must accrue to transform into a fully malignant cancer. It follows …
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
The BCL-2 protein family determines the commitment of cells to apoptosis, an ancient cell
suicide programme that is essential for development, tissue homeostasis and immunity. Too …
suicide programme that is essential for development, tissue homeostasis and immunity. Too …
Of the many cellular responses activated by TP53, which ones are critical for tumour suppression?
AF Thomas, GL Kelly, A Strasser - Cell Death & Differentiation, 2022 - nature.com
The tumour suppressor TP53 is a master regulator of several cellular processes that
collectively suppress tumorigenesis. The TP53 gene is mutated in~ 50% of human cancers …
collectively suppress tumorigenesis. The TP53 gene is mutated in~ 50% of human cancers …