The microtubule-based spindle orchestrates chromosome segregation during cell division.
Following more than a century of study, many components and pathways contributing to …

In contrast to well-studied fungal and animal cells, plant cells assemble bipolar spindles that
exhibit a great deal of plasticity in the absence of structurally defined microtubule-organizing …

Faithful chromosome segregation depends on the ability of sister kinetochores to attach to
spindle microtubules. The outer layer of kinetochores transiently expands in early mitosis to …

During cell division, kinetochore microtubules (KMTs) provide a physical linkage between
the chromosomes and the rest of the spindle. KMTs in mammalian cells are organized into …

Mitotic spindle microtubules (MT s) undergo continuous poleward flux, whose driving force
and function in humans remain unclear. Here, we combined loss‐of‐function screenings …

During cell division, mitotic spindle microtubules segregate chromosomes by exerting forces
on kinetochores. What forces drive chromosome segregation in anaphase remains a central …

During metaphase, chromosome position at the spindle equator is regulated by the forces
exerted by kinetochore microtubules and polar ejection forces. However, the role of forces …

During metaphase, chromosomes are aligned in a lineup at the equatorial plane of the
spindle to ensure synchronous poleward movement of chromatids in anaphase and proper …

Mitotic spindle assembly is crucial for chromosome segregation and relies on bundles of
microtubules that extend from the poles and overlap in the middle. However, how these …

Cytokinesis is the final event of the cell cycle dividing one cell into two daughter cells. The
protein regulator of cytokinesis (PRC) 1 is essential for cytokinesis and normal cell cleavage …