With new data about different aspects of schizophrenia being continually generated, it
becomes necessary to periodically revisit exactly what we know. Along with a need to review …

Schizophrenia has been an evolutionary paradox: it has high heritability, but it is associated
with decreased reproductive success. The causal genetic variants underlying schizophrenia …

Dysfunction of brain resting-state functional networks has been widely reported in
psychiatric disorders. However, the causal relationships between brain resting-state …

Autism spectrum disorder (ASD) and schizophrenia (SCZ) are separate disorders, with
distinct clinical profiles and natural histories. ASD, typically diagnosed in childhood, is …

This article casts a critical eye over the development of American psychiatry from 1980 to the
present. It notes the rapid decline of psychoanalysis that followed the publication of DSM III; …

This review describes the Hierarchical Taxonomy of Psychopathology (HiTOP) model of
psychosis-related psychopathology, the psychosis superspectrum. The HiTOP psychosis …

Abstract The Human Genome Project was undertaken primarily to discover genetic causes
and better treatments for human diseases. Schizophrenia was targeted since three of the …

Abstract Background and Hypothesis Schizophrenia has been robustly associated with
multiple genetic and environmental risk factors. Childhood adversity is one of the most …

Nutrition and metabolism modify epigenetic signatures like histone acetylation and DNA
methylation. Histone acetylation and DNA methylation in the central nervous system (CNS) …

Schizophrenia is a severe mental disorder with a chronic, progressive course. The etiology
of this condition is linked to the interactions of multiple genes and environmental factors. The …