[HTML][HTML] Differentiation of human pluripotent stem cells into colonic organoids via transient activation of BMP signaling

JO Múnera, N Sundaram, SA Rankin, D Hill, C Watson… - Cell stem cell, 2017 - cell.com
Gastric and small intestinal organoids differentiated from human pluripotent stem cells
(hPSCs) have revolutionized the study of gastrointestinal development and disease. Distal …

Methods and systems for converting precursor cells into intestinal tissues through directed differentiation

JM Wells, AM Zorn, JR Spence, NF Shroyer - US Patent 10,781,425, 2020 - Google Patents
2017-07-07 Assigned to CHILDREN'S HOSPITAL MEDICAL CENTER reassignment
CHILDREN'S HOSPITAL MEDICAL CENTER ASSIGNMENT OF ASSIGNORS INTEREST …

Methods and systems for converting precursor cells into gastric tissues through directed differentiation

JM Wells, KW Mccracken - US Patent 11,053,477, 2021 - Google Patents
US11053477B2 - Methods and systems for converting precursor cells into gastric tissues
through directed differentiation - Google Patents US11053477B2 - Methods and systems for …

Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same

J Wells, K McCracken - US Patent 11,066,650, 2021 - Google Patents
The instant disclosure relates to methods for converting mammalian definitive endoderm
(DE) cells into specific tissue (s) or organ (s) through directed differentiation. In particular, the …

Colonic organoids and methods of making and using same

JM Wells, JO Munera - US Patent App. 18/473,619, 2024 - Google Patents
NFVJNJQRWPQVOA-UHFFFAOYSA-N n-[2-chloro-5-(trifluoromethyl) phenyl]-2-[3-(4-ethyl-5-
ethylsulfanyl-1, 2, 4-triazol-3-yl) piperidin-1-yl] acetamide Chemical compound CCN1C …

Method of making in vivo human small intestine organoids from pluripotent stem cells

JM Wells, CL Watson, JO Munera, MM Mahe… - US Patent …, 2023 - Google Patents
2017-05-17 Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), US DEPT. OF HEALTH
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …

Colonic organoids and methods of making and using same

JM Wells, JO Munera - US Patent 11,767,515, 2023 - Google Patents
Disclosed herein are methods for the in vitro differentiation of a precursor cell into definitive
endoderm, which may further be differentiated into a human colonic organoid (HCO), via …