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[HTML][HTML] Hox genes and regional patterning of the vertebrate body plan
Several decades have passed since the discovery of Hox genes in the fruit fly Drosophila
melanogaster. Their unique ability to regulate morphologies along the anteroposterior (AP) …
melanogaster. Their unique ability to regulate morphologies along the anteroposterior (AP) …
Hox patterning of the vertebrate axial skeleton
DM Wellik - Developmental dynamics: an official publication of …, 2007 - Wiley Online Library
The axial skeleton in all vertebrates is composed of similar components that extend from
anterior to posterior along the body axis: the occipital skull bones and cervical, thoracic …
anterior to posterior along the body axis: the occipital skull bones and cervical, thoracic …
A promoter-level mammalian expression atlas
Nature, 2014 - nature.com
Regulated transcription controls the diversity, developmental pathways and spatial
organization of the hundreds of cell types that make up a mammal. Using single-molecule …
organization of the hundreds of cell types that make up a mammal. Using single-molecule …
[HTML][HTML] Hox genes in development and beyond
KA Hubert, DM Wellik - Development, 2023 - journals.biologists.com
Hox genes encode evolutionarily conserved transcription factors that are essential for the
proper development of bilaterian organisms. Hox genes are unique because they are …
proper development of bilaterian organisms. Hox genes are unique because they are …
CRISPR and biochemical screens identify MAZ as a cofactor in CTCF-mediated insulation at Hox clusters
CCCTC-binding factor (CTCF) is critical to three-dimensional genome organization. Upon
differentiation, CTCF insulates active and repressed genes within Hox gene clusters. We …
differentiation, CTCF insulates active and repressed genes within Hox gene clusters. We …
CTCF-mediated topological boundaries during development foster appropriate gene regulation
The genome is organized into repeating topologically associated domains (TADs), each of
which is spatially isolated from its neighbor by poorly understood boundary elements …
which is spatially isolated from its neighbor by poorly understood boundary elements …
Teleost Hox code defines regional identities competent for the formation of dorsal and anal fins
U Adachi, R Koita, A Seto, A Maeno, A Ishizu… - Proceedings of the …, 2024 - pnas.org
The dorsal and anal fins can vary widely in position and length along the anterior–posterior
axis in teleost fishes. However, the molecular mechanisms underlying the diversification of …
axis in teleost fishes. However, the molecular mechanisms underlying the diversification of …
Reassessing the role of Hox genes during vertebrate development and evolution
Since their discovery Hox genes have been at the core of the established models explaining
the development and evolution of the vertebrate body plan as well as its paired …
the development and evolution of the vertebrate body plan as well as its paired …
Chapter six Hox networks and the origins of motor neuron diversity
Motor behaviors are the primary means by which animals interact with their environment,
forming the final output of most central nervous system (CNS) activity. The neural circuits that …
forming the final output of most central nervous system (CNS) activity. The neural circuits that …
A panel of novel detection and prognostic methylated DNA markers in primary non–small cell lung cancer and serum DNA
Purpose: To establish a novel panel of cancer-specific methylated genes for cancer
detection and prognostic stratification of early-stage non–small cell lung cancer (NSCLC) …
detection and prognostic stratification of early-stage non–small cell lung cancer (NSCLC) …