The balance between bone forming cells (osteoblasts/osteocytes) and bone resorbing cells
(osteoclasts) plays a crucial role in tissue homeostasis and bone repair. Several hormones …

Recent advances in deep sequencing technologies have revealed that, while less than 2%
of the human genome is transcribed into mRNA for protein synthesis, over 80% of the …

Effective bone regeneration through tissue engineering requires a combination of
osteogenic progenitors, osteoinductive biofactors and biocompatible scaffold materials …

Skin injury is repaired through a multi-phase wound healing process of tissue granulation
and re-epithelialization. Any failure in the healing process may lead to chronic non-healing …

Abstract Treatment of complex bone fracture diseases is still a complicated problem that is
urged to be solved in orthopedics. In bone tissue engineering, the use of mesenchymal …

Mesenchymal stem cells (MSCs) are extensively researched for therapeutic applications in
tissue engineering and show significant potential for clinical use. Intrinsic or extrinsic factors …

Mesenchymal stem cells (MSCs) originate from many sources, including the bone marrow
and adipose tissue, and differentiate into various cell types, such as osteoblasts and …

Mesenchymal stem cells (MSCs) are multipotent progenitors that have the ability to
differentiate into multiple lineages, including bone, cartilage, and fat. We previously …

Bone formation is critically needed in orthopedic clinical practice. We found that, bone
morphogenetic protein-7 (BMP-7) gene expression was significantly increased in fractured …

Osteogenic differentiation is a tightly regulated process realized by progenitor cell
osteoblasts. Notch signaling pathway plays a critical role in skeletal development and bone …