Malaria is a devastating infectious disease that is caused by blood-borne apicomplexan
parasites of the genus Plasmodium. These pathogens have a complex lifecycle, which …

The malaria parasite life cycle alternates between two hosts: a vertebrate and the female
Anopheles mosquito vector. Cell division, proliferation, and invasion are essential for …

Malaria parasite infection is initiated by the mosquito-transmitted sporozoite stage, a highly
motile invasive cell that targets hepatocytes in the liver for infection. A promising approach to …

Plasmodium sporozoites are transmitted from infected mosquitoes to mammals, and must
navigate the host skin and vasculature to infect the liver. This journey requires distinct …

Plasmodium sporozoite transmission is a critical population bottleneck in parasite life-cycle
progression and, hence, a target for prophylactic drugs and vaccines. The recent progress of …

The prodigious rate at which malaria parasites proliferate during asexual blood-stage
replication, midgut sporozoite production, and intrahepatic development creates a …

Background Gene expression is controlled at multiple levels, including transcription,
stability, translation, and degradation. Over the years, it has become apparent that …

Plasmodium parasites have a complex life cycle alternating between a mosquito and a
vertebrate host. Following the bite of an Anopheles female mosquito, Plasmodium …

P. falciparum phenotypic plasticity is linked to the variant expression of clonal multigene
families such as the var genes. We have examined changes in transcription and histone …

Background Following fertilization, the early proteomes of metazoans are defined by the
translation of stored but repressed transcripts; further embryonic development relies on de …