Regulation of inflammation by the antioxidant haem oxygenase 1

NK Campbell, HK Fitzgerald, A Dunne - Nature Reviews Immunology, 2021‏ - nature.com
Abstract Haem oxygenase 1 (HO-1), an inducible enzyme responsible for the breakdown of
haem, is primarily considered an antioxidant, and has long been overlooked by …

[HTML][HTML] Potential implications of quercetin in autoimmune diseases

P Shen, W Lin, X Deng, X Ba, L Han, Z Chen… - Frontiers in …, 2021‏ - frontiersin.org
Autoimmune diseases are a worldwide health problem with growing rates of morbidity, and
are characterized by breakdown and dysregulation of the immune system. Although their …

Therapeutic potential of flavonoids in pain and inflammation: mechanisms of action, pre-clinical and clinical data, and pharmaceutical development

CR Ferraz, TT Carvalho, MF Manchope, NA Artero… - Molecules, 2020‏ - mdpi.com
Pathological pain can be initiated after inflammation and/or peripheral nerve injury. It is a
consequence of the pathological functioning of the nervous system rather than only a …

Quercetin alleviates rheumatoid arthritis by inhibiting neutrophil inflammatory activities

K Yuan, Q Zhu, Q Lu, H Jiang, M Zhu, X Li… - The Journal of nutritional …, 2020‏ - Elsevier
Rheumatoid arthritis (RA) is a prototypical autoimmune disorder mainly characterized by
joint inflammation and cartilage destruction. Neutrophils actively take part in the initiation …

Naturally derived heme-oxygenase 1 inducers and their therapeutic application to immune-mediated diseases

SC Funes, M Rios, A Fernández-Fierro… - Frontiers in …, 2020‏ - frontiersin.org
Heme oxygenase (HO) is the primary antioxidant enzyme involved in heme group
degradation. A variety of stimuli triggers the expression of the inducible HO-1 isoform, which …

A multifunctional nanoaggregate‐based system for detection of rheumatoid arthritis via optoacoustic/NIR‐II fluorescent imaging and therapy via inhibiting JAK‐STAT …

J Chen, L Chen, Z She, F Zeng, S Wu - Aggregate, 2024‏ - Wiley Online Library
Rheumatoid arthritis (RA) is a debilitating autoimmune disease that causes chronic pain and
serious complications, presenting a significant challenge to treat. Promising approaches for …

High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging

J Chen, U Sivan, SL Tan, L Lippo, J De Angelis… - Science …, 2021‏ - science.org
Blood vessels provide supportive microenvironments for maintaining tissue functions. Age-
associated vascular changes and their relation to tissue aging and pathology are poorly …

Flavonoids and flavonoid-based nanoparticles for osteoarthritis and rheumatoid arthritis management

H Wahnou, Y Limami, M Oudghiri - BioChem, 2024‏ - mdpi.com
Arthritis, a global health burden comprising osteoarthritis and rheumatoid arthritis, demands
advanced therapeutic approaches. In this context, flavonoids, a diverse group of naturally …

Efficacy and safety of dietary polyphenols in rheumatoid arthritis: A systematic review and meta-analysis of 47 randomized controlled trials

Z Long, W **ang, Q He, W **ao, H Wei, H Li… - Frontiers in …, 2023‏ - frontiersin.org
Objective To evaluate safety and efficacy of dietary polyphenols in the treatment of
rheumatoid arthritis (RA). Methods CNKI, Pubmed, Cochrane library, Embase were …

Rheumatoid arthritis molecular targets and their importance to flavonoid‐based therapy

AT Rufino, M Freitas, C Proença… - Medicinal Research …, 2024‏ - Wiley Online Library
Rheumatoid arthritis (RA) is a progressive, chronic, autoimmune, inflammatory, and systemic
condition that primarily affects the synovial joints and adjacent tissues, including bone …