Mitochondrial DNA (mtDNA) damage is associated with the development of cardiovascular
diseases. Cardiac aging plays a central role in cardiovascular diseases. There is …

Investigators acknowledge the limitations of rodent or non-human primate stroke models,
hundreds of putative neuroprotectants have been evaluated in preclinical models, but not …

The molecular signatures of cells in the brain have been revealed in unprecedented detail,
yet the ageing-associated genome-wide expression changes that may contribute to …

In recent years, cannabidiol (CBD), a non‐psychotropic cannabinoid, has garnered
substantial interest in drug development due to its broad pharmacological activity and multi …

Diabetes mellitus and related disorders significantly contribute to morbidity and mortality
worldwide. Despite the advances in the current therapeutic methods, further development of …

Cerebral small vessel disease (SVD) is characterized by changes in the pial and
parenchymal microcirculations. SVD produces reductions in cerebral blood flow and …

Age-related blood-brain barrier (BBB) disruption and cerebromicrovascular rarefaction
contribute importantly to the pathogenesis of both vascular cognitive impairment and …

Endothelial cell dysfunction and diabetic vascular complications are intrinsically linked.
Although BDNF plays a protective role in cerebral microvascular complications caused by …

Morbidity and mortality from diabetes mellitus and associated illnesses is a major problem
across the globe. Anti-diabetic medicines must be improved despite existing breakthroughs …

Cerebral microbleeds (CMBs) are a disorder of cerebral microvessels that are characterized
as small (< 10 mm), hypointense, round or ovoid lesions seen on T2*-weighted gradient …