2021 Update on MRD in acute myeloid leukemia: a consensus document from the European LeukemiaNet MRD Working Party

M Heuser, SD Freeman… - Blood, The Journal …, 2021 - ashpublications.org
Measurable residual disease (MRD) is an important biomarker in acute myeloid leukemia
(AML) that is used for prognostic, predictive, monitoring, and efficacy-response …

Impact of conditioning intensity of allogeneic transplantation for acute myeloid leukemia with genomic evidence of residual disease

CS Hourigan, LW Dillon, G Gui, BR Logan… - Journal of Clinical …, 2020 - ascopubs.org
PURPOSE Patients with acute myeloid leukemia (AML) in remission remain at risk for
relapse even after allogeneic hematopoietic cell transplantation (alloHCT). AML measurable …

Novel tools for diagnosis and monitoring of AML

F Guijarro, M Garrote, N Villamor, D Colomer… - Current …, 2023 - mdpi.com
In recent years, major advances in the understanding of acute myeloid leukemia (AML)
pathogenesis, together with technological progress, have led us into a new era in the …

[HTML][HTML] Measurable residual disease in acute myeloid leukemia using flow cytometry: a review of where we are and where we are going

C Dix, TH Lo, G Clark, E Abadir - Journal of clinical medicine, 2020 - mdpi.com
The detection of measurable residual disease (MRD) has become a key investigation that
plays a role in the prognostication and management of several hematologic malignancies …

Clinical impact of panel-based error-corrected next generation sequencing versus flow cytometry to detect measurable residual disease (MRD) in acute myeloid …

N Patkar, C Kakirde, AF Shaikh, R Salve, P Bhanshe… - Leukemia, 2021 - nature.com
We accrued 201 patients of adult AML treated with conventional therapy, in morphological
remission, and evaluated MRD using sensitive error-corrected next generation sequencing …

[HTML][HTML] Minimal residual disease monitoring with next-generation sequencing methodologies in hematological malignancies

R Sánchez, R Ayala, J Martínez-López - International Journal of …, 2019 - mdpi.com
Ultra-deep next-generation sequencing has emerged in recent years as an important
diagnostic tool for the detection and follow-up of tumor burden in most of the known …

Next-generation sequencing in the diagnosis and minimal residual disease assessment of acute myeloid leukemia

RL Levine, PJM Valk - Haematologica, 2019 - pmc.ncbi.nlm.nih.gov
Risk-stratification of acute myeloid leukemia (AML) based on recurrent somatic
abnormalities has evolved substantially in recent years, as illustrated by the current 2017 …

Achieving MRD negativity in AML: how important is this and how do we get there?

CS Hourigan - Hematology, 2022 - ashpublications.org
Multiple studies have demonstrated that patients with acute myeloid leukemia (AML) who
have measurable residual disease (MRD) detected during or after treatment have higher …

Next‐generation sequencing for measurable residual disease detection in acute myeloid leukaemia

J Ghannam, LW Dillon… - British journal of …, 2020 - Wiley Online Library
Acute myeloid leukaemia (AML) is a blood cancer characterized by acquired genetic
mutations. There is great interest in accurately establishing measurable residual disease …

MRD evaluation of AML in clinical practice: are we there yet?

SD Freeman, CS Hourigan - Hematology 2014, the American …, 2019 - ashpublications.org
MRD technologies increase our ability to measure response in acute myeloid leukemia
(AML) beyond the limitations of morphology. When applied in clinical trials, molecular and …