Snake venoms in drug discovery: Valuable therapeutic tools for life saving

T Mohamed Abd El-Aziz, AG Soares, JD Stockand - Toxins, 2019 - mdpi.com
Animal venoms are used as defense mechanisms or to immobilize and digest prey. In fact,
venoms are complex mixtures of enzymatic and non-enzymatic components with specific …

Haemostatically active proteins in snake venoms

T Sajevic, A Leonardi, I Križaj - Toxicon, 2011 - Elsevier
Snake venom proteins that affect the haemostatic system can cause (a) lowering of blood
coagulability,(b) damage to blood vessels, resulting in bleeding,(c) secondary effects of …

Bleeding and Thrombosis: Insights into Pathophysiology of Bothrops Venom-Related Hemostasis Disorders

S Larréché, JP Chippaux, L Chevillard… - International Journal of …, 2021 - mdpi.com
Toxins from Bothrops venoms targeting hemostasis are responsible for a broad range of
clinical and biological syndromes including local and systemic bleeding, incoagulability …

Triterpenoid saponins, new metalloprotease snake venom inhibitors isolated from Pentaclethra macroloba

JO da Silva, RS Fernandes, FK Ticli, CZ Oliveira… - Toxicon, 2007 - Elsevier
We report here the antiproteolytic and antihemorrhagic properties of triterpenoid saponin
inhibitors, named macrolobin-A and B, from Pentaclethra macroloba, against Bothrops …

Bioactive molecules derived from snake venoms with therapeutic potential for the treatment of thrombo-cardiovascular disorders associated with COVID-19

F Cherifi, F Laraba-Djebari - The protein journal, 2021 - Springer
As expected, several new variants of Severe Acute Respiratory Syndrome-CoronaVirus-2
(SARS-CoV-2) emerged and have been detected around the world throughout this …

[KİTAP][B] Venomous Reptiles of the United States, Canada, and Northern Mexico: Crotalus

CH Ernst, EM Ernst - 2011 - books.google.com
2012 Outstanding Academic Title, Choice Magazine Carl H. and Evelyn M. Ernst have
completely revised their landmark reference Venomous Reptiles of North America to present …

[HTML][HTML] Antiophidic activity of the extract of the Amazon plant Humirianthera ampla and constituents

MA Strauch, MA Tomaz, M Monteiro-Machado… - Journal of …, 2013 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: Although serotherapy against snakebite has
been discovered more than one hundred years ago, antivenom is not available all over …

[HTML][HTML] Biochemical characterization and comparative analysis of two distinct serine proteases from Bothrops pirajai snake venom

DL Menaldo, CP Bernardes, NA Santos-Filho… - Biochimie, 2012 - Elsevier
This study reports the isolation and biochemical characterization of two different serine
proteases from Bothrops pirajai snake venom, thus providing a comparative analysis of the …

Clinical and Evolutionary Implications of Dynamic Coagulotoxicity Divergences in Bothrops (Lancehead Pit Viper) Venoms

LA Bourke, CN Zdenek, AM Tanaka-Azevedo… - Toxins, 2022 - mdpi.com
Despite coagulotoxicity being a primary weapon for prey capture by Bothrops species
(lancehead pit vipers) and coagulopathy being a major lethal clinical effect, a genus-wide …

Serine proteinases from Bothrops snake venom activates PI3K/Akt mediated angiogenesis

SK Bhat, MB Joshi, A Ullah, R Masood, SG Biligiri… - Toxicon, 2016 - Elsevier
The discovery of rapid acting and powerful angiogenic proteins are of significant interest in
the treatment of various human disorders associated with insufficient angiogenesis such as …