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Protein misfolding and amyloid nucleation through liquid–liquid phase separation
Liquid–liquid phase separation (LLPS) is an emerging phenomenon in cell physiology and
diseases. The weak multivalent interaction prerequisite for LLPS is believed to be facilitated …
diseases. The weak multivalent interaction prerequisite for LLPS is believed to be facilitated …
Fundamental aspects of phase-separated biomolecular condensates
Biomolecular condensates, formed through phase separation, are upending our
understanding in much of molecular, cell, and developmental biology. There is an urgent …
understanding in much of molecular, cell, and developmental biology. There is an urgent …
Single-molecule FRET unmasks structural subpopulations and crucial molecular events during FUS low-complexity domain phase separation
Biomolecular condensates formed via phase separation of proteins and nucleic acids are
thought to be associated with a wide range of cellular functions and dysfunctions. We dissect …
thought to be associated with a wide range of cellular functions and dysfunctions. We dissect …
Multicompartmental coacervate-based protocell by spontaneous droplet evaporation
Hierarchical compartmentalization, a hallmark of both primitive and modern cells, enables
the concentration and isolation of biomolecules, and facilitates spatial organization of …
the concentration and isolation of biomolecules, and facilitates spatial organization of …
Role of aberrant phase separation in pathological protein aggregation
Neurodegenerative diseases are associated with the pathological deposition of many
different intrinsically disordered proteins or proteins with intrinsically disordered regions …
different intrinsically disordered proteins or proteins with intrinsically disordered regions …
Challenges in studying the liquid-to-solid phase transitions of proteins using computer simulations
Abstract “Membraneless organelles,” also referred to as biomolecular condensates, perform
a variety of cellular functions and their dysregulation is implicated in cancer and …
a variety of cellular functions and their dysregulation is implicated in cancer and …
β-synuclein regulates the phase transitions and amyloid conversion of α-synuclein
X Li, L Yu, X Liu, T Shi, Y Zhang, Y **ao… - Nature …, 2024 - nature.com
Parkinson's disease (PD) and Dementia with Lewy Bodies (DLB) are neurodegenerative
disorders characterized by the accumulation of α-synuclein aggregates. α-synuclein forms …
disorders characterized by the accumulation of α-synuclein aggregates. α-synuclein forms …
Hydrogen-bonded network of water in phase-separated biomolecular condensates
Biomolecular condensates formed via phase separation of intrinsically disordered
proteins/regions (IDPs/IDRs) and nucleic acids are associated with cell physiology and …
proteins/regions (IDPs/IDRs) and nucleic acids are associated with cell physiology and …
[HTML][HTML] Liquid− liquid phase separation of tau: Driving forces, regulation, and biological implications
P Li, J Chen, X Wang, Z Su, M Gao, Y Huang - Neurobiology of Disease, 2023 - Elsevier
The past 15 years have witnessed an explosion in the studies of biomolecular condensates
that are implicated in numerous biological processes and play vital roles in human health …
that are implicated in numerous biological processes and play vital roles in human health …
Enzyme-mediated temporal control over the conformational disposition of a condensed protein in macromolecular crowded media
Temporal regulation between input and output signals is one of the hallmarks of complex
biological processes. Herein, we report that the conformational disposition of a protein in …
biological processes. Herein, we report that the conformational disposition of a protein in …