Sickle cell disease is caused by an alteration in a single DNA base, but its clinical
manifestations are influenced by other genes and behavioral and environmental factors …

Sickle-cell disease is one of the most common severe monogenic disorders in the world.
Haemoglobin polymerisation, leading to erythrocyte rigidity and vaso-occlusion, is central to …

Although information about the precise world distribution and frequency of the inherited
hemoglobin disorders is still limited, there is no doubt that they are going to pose an …

Malaria has been the pre-eminent cause of early mortality in many parts of the world
throughout much of the last five thousand years and, as a result, it is the strongest force for …

Clinical manifestations of Plasmodium falciparum infection are induced by the asexual
stages of the parasite that develop inside red blood cells (RBCs). Because splenic …

The spleen has a combined function of immune defence and quality control of senescent or
altered red cells. It is the first organ injured in sickle cell anaemia (SCA) with evidence of …

Sickle cell disease has been largely an invisible global health issue, especially in regions of
high incidence mainly due to lack of awareness among both the local health policy makers …

Sickle cell disease (SCD) results in chronic hemolytic anemia, recurrent vascular occlusion,
insidious vital organ deterioration, early mortality, and diminished quality of life. Life …

In spite of significant strides in the treatment of sickle cell disease (SCD), SCD crises are still
responsible for high morbidity and early mortality. While most patients initially seek care in …

Background Sickle cell disease contributes substantially to mortality in children younger
than 5 years in sub-Saharan Africa. In Uganda, 20 000 babies per year are thought to be …