Genistein: an integrative overview of its mode of action, pharmacological properties, and health benefits

J Sharifi-Rad, C Quispe, M Imran, A Rauf… - Oxidative medicine …, 2021 - Wiley Online Library
Genistein is an isoflavone first isolated from the brooming plant Dyer's Genista tinctoria L.
and is widely distributed in the Fabaceae family. As an isoflavone, mammalian genistein …

[HTML][HTML] Current perspectives on the beneficial effects of soybean isoflavones and their metabolites for humans

IS Kim - Antioxidants, 2021 - mdpi.com
Soybeans are rich in proteins and lipids and have become a staple part of the human diet.
Besides their nutritional excellence, they have also been shown to contain various functional …

[HTML][HTML] Cancer prevention and therapy through the modulation of the tumor microenvironment

SC Casey, A Amedei, K Aquilano, AS Azmi… - Seminars in cancer …, 2015 - Elsevier
Cancer arises in the context of an in vivo tumor microenvironment. This microenvironment is
both a cause and consequence of tumorigenesis. Tumor and host cells co-evolve …

[HTML][HTML] Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents

S Hashem, TA Ali, S Akhtar, S Nisar, G Sageena… - Biomedicine & …, 2022 - Elsevier
Cancer is one of the leading causes of death and significantly burdens the healthcare
system. Due to its prevalence, there is undoubtedly an unmet need to discover novel …

Comprehensive and critical view on the anti-inflammatory and immunomodulatory role of natural phenolic antioxidants

AM Pisoschi, F Iordache, L Stanca, C Cimpeanu… - European Journal of …, 2024 - Elsevier
The immune response encompasses innate and adaptive immunity, each with distinct and
specific activities. The innate immune system is constituted by phagocytic cells …

Evaluation of the antitumor immune responses of probiotic Bifidobacterium bifidum in human papillomavirus-induced tumor model

E Abdolalipour, M Mahooti, A Salehzadeh… - Microbial …, 2020 - Elsevier
As of present, a number of studies have shown anti-cancer effects of different strains of
probiotics, but the precise host immunological mechanisms of these antitumor effects remain …

[HTML][HTML] A multi-targeted approach to suppress tumor-promoting inflammation

AK Samadi, A Bilsland, AG Georgakilas… - Seminars in cancer …, 2015 - Elsevier
Cancers harbor significant genetic heterogeneity and patterns of relapse following many
therapies are due to evolved resistance to treatment. While efforts have been made to …

[HTML][HTML] Effects of genistein supplementation on genome‑wide DNA methylation and gene expression in patients with localized prostate cancer

B Bilir, NV Sharma, J Lee… - International …, 2017 - spandidos-publications.com
Epidemiological studies have shown that dietary compounds have significant effects on
prostate carcinogenesis. Among dietary agents, genistein, the major isoflavone in soybean …

Potential mechanisms of plant-derived natural products in the treatment of cervical cancer

M He, L **a, J Li - Biomolecules, 2021 - mdpi.com
Cervical cancer is the second most common gynecological malignancy globally; it seriously
endangers women's health because of its high morbidity and mortality. Conventional …

A Comprehensive Review of Genistein's Effects in Preclinical Models of Cervical Cancer

M Nadile, A Kornel, NSK Sze, E Tsiani - Cancers, 2023 - mdpi.com
Simple Summary Cervical cancer is the fourth most commonly diagnosed cancer among
women worldwide. While treatments exist to stop growth of cervical cancer in humans, they …