The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …

Immunotherapy is often perceived as a relatively recent advance. In reality, however, one
should be looking for the beginnings of cancer immunotherapy under different names as far …

Drug conjugates are chemotherapeutic or cytotoxic agents covalently linked to targeting
ligands such as an antibody or a peptide via a linker. While antibody–drug conjugates …

Cancer became recently the leading cause of death in industrialized countries. Even though
standard treatments achieve significant effects in growth inhibition and tumor elimination …

Background Pancreatic cancer is one of the most lethal type of cancers, with an overall five-
year survival rate of less than 5%. It is usually diagnosed at an advanced stage with limited …

Legumain (LGMN) has been demonstrated to be overexpressed not just in breast, prostatic,
and liver tumor cells, but also in the macrophages that compose the tumor …

The cysteine protease legumain (also known as asparaginyl endopeptidase or δ-secretase)
is the only known mammalian asparaginyl endopeptidase and is primarily localized to the …

Cancer has become the primary reason for industrial countries death. Although first-line
treatments have achieved remarkable results in inhibiting tumors, they could have serious …

Metastasis is known as the most life-threatening event in cancer patients. In principle, the
immune system can prevent tumor development. However, dysfunctional T cells may fail to …

This dissertation traces the historical trajectory of cancer immunotherapy, beginning with
early attempts at vaccination in ancient civilizations to the development of monoclonal …