Changing demographics make it ever more important to understand the modifiable risk
factors for disability and loss of independence with advancing age. For more than two …

Skeletal muscle weakness occurs with aging and in females this is compounded by the loss
of estrogen with ovarian failure. Estrogen deficiency mediates decrements in muscle …

Due to improved health care, diet and infrastructure in developed countries, since 1840 life
expectancy has increased by approximately 2 years per decade. Accordingly, by 2050, a …

The development of clinical interventions that significantly improve human healthspan
requires robust markers of biological age as well as thoughtful therapeutic targets. To …

The progressive loss of skeletal muscle mass and concomitant reduction in contractile
strength plays a central role in frailty syndrome. Age-related neuronal impairments are …

Aging is characterized by a progressive loss of muscle mass and muscle strength. Declines
in skeletal muscle mitochondria are thought to play a primary role in this process …

Skeletal muscle health is dependent on the optimal function of its mitochondria. With
advancing age, decrements in numerous mitochondrial variables are evident in muscle. Part …

Ageing is associated with a progressive degeneration of the tissues, which has a negative
impact on the structure and function of vital organs and is among the most important known …

OBJECTIVE Insulin resistance in skeletal muscle is an early phenomenon in the
pathogenesis of type 2 diabetes. Studies of insulin resistance usually are highly focused …

The aging process has been linked to the occurrence of chronic diseases and functional
impairments, including cancer, sarcopenia, frailty, metabolic, cardiovascular, and …