Towards the elimination of chronic obstructive pulmonary disease: a Lancet Commission
Executive summary Despite substantial progress in reducing the global impact of many non-
communicable diseases, including heart disease and cancer, morbidity and mortality due to …
communicable diseases, including heart disease and cancer, morbidity and mortality due to …
The tobacco smoke component, acrolein, as a major culprit in lung diseases and respiratory cancers: Molecular mechanisms of acrolein cytotoxic activity
P Hikisz, D Jacenik - Cells, 2023 - mdpi.com
Acrolein, a highly reactive unsaturated aldehyde, is a ubiquitous environmental pollutant
that seriously threatens human health and life. Due to its high reactivity, cytotoxicity and …
that seriously threatens human health and life. Due to its high reactivity, cytotoxicity and …
Dupilumab for COPD with blood eosinophil evidence of type 2 inflammation
Background Dupilumab, a fully human monoclonal antibody that blocks the shared receptor
component for interleukin-4 and interleukin-13, key and central drivers of type 2 …
component for interleukin-4 and interleukin-13, key and central drivers of type 2 …
Global burden of chronic obstructive pulmonary disease through 2050
Importance Chronic obstructive pulmonary disease (COPD) is a respiratory condition that is
associated with significant health and economic burden worldwide. Previous studies …
associated with significant health and economic burden worldwide. Previous studies …
[HTML][HTML] Cathepsin S (CTSS) activity in health and disease-A treasure trove of untapped clinical potential
P Smyth, J Sasiwachirangkul, R Williams… - Molecular aspects of …, 2022 - Elsevier
Amongst the lysosomal cysteine cathepsin family of proteases, cathepsin S (CTSS) holds
particular interest due to distinctive properties including a normal restricted expression …
particular interest due to distinctive properties including a normal restricted expression …
Identifying risk factors for COPD and adult-onset asthma: an umbrella review
JCS Holtjer, LD Bloemsma, RJ Beijers… - European …, 2023 - Eur Respiratory Soc
Background COPD and adult-onset asthma (AOA) are the most common noncommunicable
respiratory diseases. To improve early identification and prevention, an overview of risk …
respiratory diseases. To improve early identification and prevention, an overview of risk …
Mechanisms of lung damage and development of COPD due to household biomass-smoke exposure: inflammation, oxidative stress, MicroRNAs, and gene …
B Ortiz-Quintero, I Martínez-Espinosa, R Pérez-Padilla - Cells, 2022 - mdpi.com
Chronic exposure to indoor biomass smoke from the combustion of solid organic fuels is a
major cause of disease burden worldwide. Almost 3 billion people use solid fuels such as …
major cause of disease burden worldwide. Almost 3 billion people use solid fuels such as …
[HTML][HTML] Imbalance of gut microbiota is involved in the development of chronic obstructive pulmonary disease: a review
W Song, Y Yue, Q Zhang - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a common chronic disease characterized
by chronic airway inflammation and remodeling, which seriously endangers human health …
by chronic airway inflammation and remodeling, which seriously endangers human health …
[HTML][HTML] Preterm birth and asthma and COPD in adulthood: a nationwide register study from two Nordic countries
A Pulakka, K Risnes, J Metsälä… - European …, 2023 - Eur Respiratory Soc
Background Preterm birth affects lungs in several ways but few studies have follow-up until
adulthood. We investigated the association of the entire spectrum of gestational ages with …
adulthood. We investigated the association of the entire spectrum of gestational ages with …
Self-amplifying RNA approach for protein replacement therapy
Messenger RNA (mRNA) technology has already been successfully tested preclinically and
there are ongoing clinical trials for protein replacement purposes; however, more effort has …
there are ongoing clinical trials for protein replacement purposes; however, more effort has …