Tremendous progress has been made since Neuron published our Primer on genetic
dissection of neural circuits 10 years ago. Since then, cell-type-specific anatomical …

Many psychiatric disorders, despite their specific characteristics, share deficits in the
cognitive domain including executive functions, emotional control and memory. However …

In the brain, neuronal gene expression is dynamically changed in response to neuronal
activity. In particular, the expression of immediate-early genes (IEGs) such as egr-1, c-fos …

Declarative memories are thought to be stored within anatomically distributed neuronal
networks requiring the hippocampus; however, it is unclear how neocortical areas …

Many excitatory synapses express Group 1, or Gq coupled, metabotropic glutamate
receptors (Gp1 mGluRs) at the periphery of their postsynaptic density. Activation of Gp1 …

Histone deacetylase (HDAC) inhibitors increase histone acetylation and enhance both
memory and synaptic plasticity. The current model for the action of HDAC inhibitors assumes …

Cerebral ischemia (stroke) triggers a complex series of biochemical and molecular
mechanisms that impairs the neurologic functions through breakdown of cellular integrity …

Homeostatic plasticity may compensate for Hebbian forms of synaptic plasticity, such as long-
term potentiation (LTP) and depression (LTD), by scaling neuronal output without changing …

Throughout adulthood, new neurons are continuously added to the dentate gyrus, a
hippocampal subregion that is important in spatial learning. Whether these adult-generated …

This review, focusing on work using animals, updates a theoretical approach whose aim is
to translate neuropsychological ideas about the psychological and anatomical organization …