Protein S‐palmitoylation is a reversible post‐translational modification that alters the
localization, stability, and function of hundreds of proteins in the cell. S‐palmitoylation is …

Deviation from a balanced genome by either gain or loss of entire chromosomes is generally
tolerated poorly in all eukaryotic systems studied to date. Errors in mitotic or meiotic cell …

Lobular neoplasia (LN) is a term that encompasses both lobular carcinoma in situ and
atypical lobular hyperplasia. These lesions have been shown to constitute both risk …

Scribble (SCRIB) is a tumor-suppressor protein, playing critical roles in establishing and
maintaining epithelial cell polarity. SCRIB is frequently amplified in human cancers but does …

Protein S-palmitoylation is a reversible posttranslational modification of proteins with fatty
acids, an enzymatic process driven by a recently discovered family of protein …

Introduction The 19q12 locus is amplified in a subgroup of oestrogen receptor (ER)-negative
grade III breast cancers. This amplicon comprises nine genes, including cyclin E1 (CCNE1) …

Lobular carcinoma in situ (LCIS) is considered to be a risk factor for the development of
invasive breast carcinoma, but it may also be a non-obligate precursor to invasive lobular …

Introduction: Palmitoylation describes the enzymatic attachment of the 16-carbon fatty acid,
palmitate, to specific cysteines of proteins via a labile thioester bond. This post-translational …

De novo or acquired resistance to endocrine therapy limits its utility in a significant number
of estrogen receptor-positive (ER-positive) breast cancers. It is crucial to identify novel …

Simple Summary Classical cytogenetic studies in breast cancer have identified frequent
chromosomal aberrations that produce an increased gene copy number in chromosome 1q …