Role of exosomes in central nervous system diseases

W Liu, X Bai, A Zhang, J Huang, S Xu… - Frontiers in molecular …, 2019 - frontiersin.org
There are many types of intercellular communication, and extracellular vesicles are one of
the important forms of this. They are released by a variety of cell types, are heterogeneous …

Military-related mild traumatic brain injury: clinical characteristics, advanced neuroimaging, and molecular mechanisms

SY Kim, PH Yeh, JM Ollinger, HD Morris… - Translational …, 2023 - nature.com
Mild traumatic brain injury (mTBI) is a significant health burden among military service
members. Although mTBI was once considered relatively benign compared to more severe …

Questions concerning the role of amyloid-β in the definition, aetiology and diagnosis of Alzheimer's disease

GP Morris, IA Clark, B Vissel - Acta neuropathologica, 2018 - Springer
The dominant hypothesis of Alzheimer's disease (AD) aetiology, the neuropathological
guidelines for diagnosing AD and the majority of high-profile therapeutic efforts, in both …

A framework to advance biomarker development in the diagnosis, outcome prediction, and treatment of traumatic brain injury

EA Wilde, IB Wanner, K Kenney, J Gill… - Journal of …, 2022 - liebertpub.com
Multi-modal biomarkers (eg, imaging, blood-based, physiological) of unique traumatic brain
injury (TBI) endophenotypes are necessary to guide the development of personalized and …

[HTML][HTML] Post-concussion syndrome and chronic traumatic encephalopathy: narrative review on the neuropathology, neuroimaging and fluid biomarkers

I Mavroudis, D Kazis, R Chowdhury, F Petridis, V Costa… - Diagnostics, 2022 - mdpi.com
Traumatic brain injury is a significant public health issue and represents the main contributor
to death and disability globally among all trauma-related injuries. Martial arts practitioners …

[HTML][HTML] Precision health: A nursing perspective

MR Fu, E Kurnat-Thoma, A Starkweather… - International journal of …, 2020 - Elsevier
Precision health refers to personalized healthcare based on a person's unique genetic,
genomic, or omic composition within the context of lifestyle, social, economic, cultural and …

Assessing neuronal and astrocyte derived exosomes from individuals with mild traumatic brain injury for markers of neurodegeneration and cytotoxic activity

CN Winston, HK Romero, M Ellisman… - Frontiers in …, 2019 - frontiersin.org
Mild traumatic brain injury (mTBI) disproportionately affects military service members and is
very difficult to diagnose. To-date, there is currently no blood-based, diagnostic biomarker …

Long-term effects of SARS-CoV-2 in the brain: clinical consequences and molecular mechanisms

AC Granholm - Journal of Clinical Medicine, 2023 - mdpi.com
Numerous investigations have demonstrated significant and long-lasting neurological
manifestations of COVID-19. It has been suggested that as many as four out of five patients …

Extracellular vesicle proteins and microRNAs as biomarkers for traumatic brain injury

VA Guedes, C Devoto, J Leete, D Sass, JD Acott… - Frontiers in …, 2020 - frontiersin.org
Traumatic brain injury (TBI) is a heterogeneous condition, associated with diverse etiologies,
clinical presentations and degrees of severity, and may result in chronic neurobehavioral …

The evolving role of extracellular vesicles (exosomes) as biomarkers in traumatic brain injury: Clinical perspectives and therapeutic implications

NA Khan, M Asim, A El-Menyar, KH Biswas… - Frontiers in aging …, 2022 - frontiersin.org
Develo** effective disease-modifying therapies for neurodegenerative diseases (NDs)
requires reliable diagnostic, disease activity, and progression indicators. While desirable …