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[HTML][HTML] Mechanisms of cardiac arrhythmias
Blood circulation is the result of the beating of the heart, which provides the mechanical
force to pump oxygenated blood to, and deoxygenated blood away from, the peripheral …
force to pump oxygenated blood to, and deoxygenated blood away from, the peripheral …
Reactive oxygen species, endoplasmic reticulum stress and mitochondrial dysfunction: the link with cardiac arrhythmogenesis
Background: Cardiac arrhythmias represent a significant problem globally, leading to
cerebrovascular accidents, myocardial infarction, and sudden cardiac death. There is …
cerebrovascular accidents, myocardial infarction, and sudden cardiac death. There is …
Molecular and electrophysiological mechanisms underlying cardiac arrhythmogenesis in diabetes mellitus
Diabetes is a common endocrine disorder with an ever increasing prevalence globally,
placing significant burdens on our healthcare systems. It is associated with significant …
placing significant burdens on our healthcare systems. It is associated with significant …
Intracellular ion accumulation in the genesis of complex action potential dynamics under cardiac diseases
Intracellular ions, including sodium (Na+), calcium (Ca 2+), and potassium (K+), etc.,
accumulate slowly after a change of the state of the heart, such as a change of the heart rate …
accumulate slowly after a change of the state of the heart, such as a change of the heart rate …
Global optimization of ventricular myocyte model to multi-variable objective improves predictions of drug-induced torsades de pointes
In silico cardiac myocyte models present powerful tools for drug safety testing and for
predicting phenotypical consequences of ion channel mutations, but their accuracy is …
predicting phenotypical consequences of ion channel mutations, but their accuracy is …
Dynamical mechanisms of phase-2 early afterdepolarizations in human ventricular myocytes: insights from bifurcation analyses of two mathematical models
Early afterdepolarization (EAD) is known as a cause of ventricular arrhythmias in long QT
syndromes. We theoretically investigated how the rapid (I Kr) and slow (I Ks) components of …
syndromes. We theoretically investigated how the rapid (I Kr) and slow (I Ks) components of …
Dynamical mechanism for generation of arrhythmogenic early afterdepolarizations in cardiac myocytes: Insights from in silico electrophysiological models
We analyze the dynamical mechanisms underlying the formation of arrhythmogenic early
afterdepolarizations (EADs) in two mathematical models of cardiac cellular …
afterdepolarizations (EADs) in two mathematical models of cardiac cellular …
Anti-arrhythmic strategies for atrial fibrillation: The role of computational modeling in discovery, development, and optimization
Atrial fibrillation (AF), the most common cardiac arrhythmia, is associated with increased risk
of cerebrovascular stroke, and with several other pathologies, including heart failure …
of cerebrovascular stroke, and with several other pathologies, including heart failure …
Multiple Dynamical Mechanisms of Phase-2 Early Afterdepolarizations in a Human Ventricular Myocyte Model: Involvement of Spontaneous SR Ca2+ Release
Early afterdepolarization (EAD) is known to cause lethal ventricular arrhythmias in long QT
syndrome (LQTS). In this study, dynamical mechanisms of EAD formation in human …
syndrome (LQTS). In this study, dynamical mechanisms of EAD formation in human …
Altered calcium handling and ventricular arrhythmias in acute ischemia
Acute ischemia results in deadly cardiac arrhythmias that are a major contributor to sudden
cardiac death (SCD). The electrophysiological changes involved have been extensively …
cardiac death (SCD). The electrophysiological changes involved have been extensively …