Cellular senescence entails a state of an essentially irreversible proliferative arrest in which
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …

Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

Retrotransposable elements are deleterious at many levels, and the failure of host
surveillance systems for these elements can thus have negative consequences. However …

The accumulation of irreparable cellular damage restricts healthspan after acute stress or
natural aging. Senescent cells are thought to impair tissue function, and their genetic …

Mutations in the TP53 tumour suppressor gene are found in~ 50% of human cancers [,,,,–].
TP53 functions as a transcription factor that directly regulates the expression of~ 500 genes …

P53 is a transcription factor highly inducible by many stress signals such as DNA damage,
oncogene activation, and nutrient deprivation. Cell-cycle arrest and apoptosis are the most …

The shortening of human telomeres has two opposing effects during cancer development.
On the one hand, telomere shortening can exert a tumour-suppressive effect through the …

The function of p53 as a tumour suppressor has been attributed to its ability to promote cell
death or permanently inhibit cell proliferation. However, in recent years, it has become clear …

Telomerase is a key enzyme for cell survival that prevents telomere shortening and the
subsequent cellular senescence that is observed after many rounds of cell division. In …

Abstract p53 functions as a transcription factor involved in cell-cycle control, DNA repair,
apoptosis and cellular stress responses. However, besides inducing cell growth arrest and …