Pathogenicity and virulence of Clostridium perfringens

I Mehdizadeh Gohari, M A. Navarro, J Li, A Shrestha… - Virulence, 2021 - Taylor & Francis
Clostridium perfringens is an extremely versatile pathogen of humans and livestock, causing
wound infections like gas gangrene (clostridial myonecrosis), enteritis/enterocolitis …

Towards an Understanding of the Role of Clostridium Perfringens Toxins in Human and Animal Disease

FA Uzal, JC Freedman, A Shrestha, JR Theoret… - Future …, 2014 - Taylor & Francis
Clostridium perfringens uses its arsenal of> 16 toxins to cause histotoxic and intestinal
infections in humans and animals. It has been unclear why this bacterium produces so many …

Intestinal microbiota as a host defense mechanism to infectious threats

S Iacob, DG Iacob, LM Luminos - Frontiers in microbiology, 2019 - frontiersin.org
The intestinal microbiota is a complex microbial community, with diverse and stable
populations hosted by the gastrointestinal tract since birth. This ecosystem holds multiple …

Epsilon toxin–producing Clostridium perfringens colonize the multiple sclerosis gut microbiome overcoming CNS immune privilege

Y Ma, D Sannino, JR Linden, S Haigh… - The Journal of …, 2023 - Am Soc Clin Investig
Multiple sclerosis (MS) is a complex disease of the CNS thought to require an environmental
trigger. Gut dysbiosis is common in MS, but specific causative species are unknown. To …

Lack of vitamin D receptor causes dysbiosis and changes the functions of the murine intestinal microbiome

D **, S Wu, Y Zhang, R Lu, Y **a, H Dong, J Sun - Clinical therapeutics, 2015 - Elsevier
Purpose The microbiome modulates numerous aspects of human physiology and is a
crucial factor in the development of various human diseases. Vitamin D deficiency and …

Vaccine production to protect animals against pathogenic clostridia

NE Zaragoza, CA Orellana, GA Moonen, G Moutafis… - Toxins, 2019 - mdpi.com
Clostridium is a broad genus of anaerobic, spore-forming, rod-shaped, Gram-positive
bacteria that can be found in different environments all around the world. The genus …

[HTML][HTML] Gossip in the gut: Quorum sensing, a new player in the host-microbiota interactions

G Coquant, D Aguanno, S Pham, N Grellier… - World Journal of …, 2021 - ncbi.nlm.nih.gov
Bacteria are known to communicate with each other and regulate their activities in social
networks by secreting and sensing signaling molecules called autoinducers, a process …

Rethinking the role of alpha toxin in Clostridium perfringens-associated enteric diseases: a review on bovine necro-haemorrhagic enteritis

E Goossens, BR Valgaeren, B Pardon… - Veterinary …, 2017 - Springer
Bovine necro-haemorrhagic enteritis is an economically important disease caused by
Clostridium perfringens type A strains. The disease mainly affects calves under intensive …

Regulation of Toxin Production in Clostridium perfringens

K Ohtani, T Shimizu - Toxins, 2016 - mdpi.com
The Gram-positive anaerobic bacterium Clostridium perfringens is widely distributed in
nature, especially in soil and the gastrointestinal tracts of humans and animals. C …

Clostridium perfringens type C necrotic enteritis in pigs: diagnosis, pathogenesis, and prevention

H Posthaus, S Kittl, B Tarek… - Journal of veterinary …, 2020 - journals.sagepub.com
Clostridium perfringens type C causes severe and lethal necrotic enteritis (NE) in newborn
piglets. NE is diagnosed through a combination of pathology and bacteriologic …