The neurotransmitter transporters (NTTs) belonging to the solute carrier 6 (SLC6) gene
family (also referred to as the neurotransmitter-sodium-symporter family or Na+/Cl …

The dopamine transporter (DAT) plays an integral role in dopamine neurotransmission
through the clearance of dopamine from the extracellular space. Dysregulation of DAT is …

Abstract Na+/Cl--dependent transporters terminate synaptic transmission by using
electrochemical gradients to drive the uptake of neurotransmitters, including the biogenic …

Neurotransmitter sodium symporters are integral membrane proteins that remove chemical
transmitters from the synapse and terminate neurotransmission mediated by serotonin …

Cocaine is a widely abused substance with psychostimulant effects that are attributed to
inhibition of the dopamine transporter (DAT). We present molecular models for DAT binding …

Eukaryotic neurotransmitter: sodium symporters (NSSs), targets for antidepressants and
psychostimulants, terminate neurotransmission by sodium-driven reuptake. The crystal …

Efflux of dopamine through the dopamine transporter (DAT) is critical for the
psychostimulatory properties of amphetamines, but the underlying mechanism is unclear …

Parkinsonism and attention deficit hyperactivity disorder (ADHD) are widespread brain
disorders that involve disturbances of dopaminergic signaling. The sodium-coupled …

BACKGROUND:(±)-Modafinil has piqued interest as a treatment for attention-
deficit/hyperactivity disorder and stimulant dependence. The R-enantiomer of modafinil …

Dopamine regulates reward, cognition, and locomotor functions. By mediating rapid
reuptake of extracellular dopamine, the dopamine transporter is critical for spatiotemporal …