Preventing and treating anthracycline cardiotoxicity: new insights

KT Sawicki, V Sala, L Prever, E Hirsch… - Annual review of …, 2021 - annualreviews.org
Anthracyclines are the cornerstone of many chemotherapy regimens for a variety of cancers.
Unfortunately, their use is limited by a cumulative dose-dependent cardiotoxicity. Despite …

Metabolic aspects of anthracycline cardiotoxicity

M Russo, A Della Sala, CG Tocchetti… - … treatment options in …, 2021 - Springer
Opinion statement Heart failure (HF) is increasingly recognized as the major complication of
chemotherapy regimens. Despite the development of modern targeted therapies such as …

Understanding anthracycline cardiotoxicity from mitochondrial aspect

J Huang, R Wu, L Chen, Z Yang, D Yan… - Frontiers in …, 2022 - frontiersin.org
Anthracyclines, such as doxorubicin, represent one group of chemotherapy drugs with the
most cardiotoxicity. Despite that anthracyclines are capable of treating assorted solid tumors …

Cardio-oncology: mechanisms, drug combinations, and reverse cardio-oncology

Z Liang, Y He, X Hu - International Journal of Molecular Sciences, 2022 - mdpi.com
Chemotherapy, radiotherapy, targeted therapy, and immunotherapy have brought hope to
cancer patients. With the prolongation of survival of cancer patients and increased clinical …

Cardiotoxicity of anticancer drugs: molecular mechanisms, clinical management and innovative treatment

F Gao, T Xu, F Zang, Y Luo, D Pan - Drug Design, Development …, 2024 - Taylor & Francis
With the continuous refinement of therapeutic measures, the survival rate of tumor patients
has been improving year by year, while cardiovascular complications related to cancer …

Cardiovascular toxic effects of antitumor agents: Pathogenetic mechanisms

D Pantazi, AD Tselepis - Thrombosis Research, 2022 - Elsevier
Cancer treatment is associated with various side effects of antitumor agents, which increase
the morbidity and mortality of these patients. Cardiovascular complications are considered to …

Saponins and their derivatives: potential candidates to alleviate anthracycline-induced cardiotoxicity and multidrug resistance

PR Qu, ZL Jiang, PP Song, LC Liu, M **ang… - Pharmacological …, 2022 - Elsevier
Anthracyclines (ANTs) continue to play an irreplaceable role in oncology treatment.
However, the clinical application of ANTs has been limited. In the first place, ANTs can …

Molecular imaging biomarkers in cardiooncology: a view on established technologies and future perspectives

D Kersting, IA Mavroeidi, S Settelmeier… - Journal of Nuclear …, 2023 - Soc Nuclear Med
Novel therapeutic options have significantly improved survival and long-term outcomes in
many cancer entities. Unfortunately, this improvement in outcome is often accompanied by …

An update of the molecular mechanisms underlying anthracycline induced cardiotoxicity

S **e, Y Sun, X Zhao, Y **ao, F Zhou, L Lin… - Frontiers in …, 2024 - frontiersin.org
Anthracycline drugs mainly include doxorubicin, epirubicin, pirarubicin, and aclamycin,
which are widely used to treat a variety of malignant tumors, such as breast cancer …

Tubeimoside I Ameliorates Doxorubicin‐Induced Cardiotoxicity by Upregulating SIRT3

W Zhang, Z Fan, F Wang, L Yin, J Wu… - Oxidative medicine …, 2023 - Wiley Online Library
Cardiotoxicity linked to doxorubicin (DOX) is primarily caused by inflammation, oxidative
stress, and apoptosis. The role of tubeimoside I (TBM) in DOX‐induced cardiotoxicity …