Human ring chromosomes (RCs) are rare diseases with an estimated newborn incidence of
1/50,000 and an annual occurrence of 2,800 patients globally. Over the past 60 years …

Human ring chromosomes are often unstable during mitosis, and daughter cells can be
partially or completely aneuploid. We studied the mitotic stability of four ring chromosomes …

Induced pluripotent stem cells (iPSCs) are generated from adult cells that have been
reprogrammed to pluripotency. However, in vitro cultivation and genetic reprogramming …

Differentiation of induced pluripotent stem cells (iPSCs) from patients and healthy donors
allows in vitro study of genetic disorders. The authors have previously reported a clinical …

Human induced pluripotent stem cells (iPSCs) are a promising source of cells for
regenerative medicine, study of the pathogenesis of various diseases, screening of …

Human ring chromosomes (RCs) are a rare type of chromosomal structural abnormality.
Current cytogenomic analysis revealed heterogeneous genomic rearrangements in the ring …

Cohen syndrome is a rare autosomal recessive genetic disorder characterized by
developmental delay, intellectual disability, microcephaly, neutropenia, dysmorphism …

Induced pluripotent stem cells (iPSCs) are beneficial for studying of chromosomal diseases,
including ring chromosomes (RCs), because iPSCs can be differentiated to various cell …

About 250 cases of ring chromosome 22 (RC22) have been reported in the literature.
Approximately 90% of RC22 cases have a deletion of the terminal band, 22q13, compatible …

Human ring chromosomes (RCs) are rare diseases with an estimated newborn incidence of
1/50,000 and an annual occurrence of 2,800 patients globally. Over the past 60 years …