O 6-Alkylguanine-DNA alkyltransferase (AGT) is a widely distributed, unique DNA repair
protein that acts as a single agent to directly remove alkyl groups located on the O 6-position …

Simple Summary This review offers a thorough examination of the potential role and
structural properties of MGMT, the progression in targeting MGMT, and the interactions …

The first nucleic acid structure to be elucidated was the BDNA antiparallel duplex with
Watson–Crick base pairs. Although B-DNA is the most common DNA structure, alternative …

Most antitumour therapies damage tumour cell DNA either directly or indirectly. Without
repair, damage can result in genetic instability and eventually cancer. The strong …

The missing linking: BCNU is a chemotherapy drug that generates an ethylene bridge
between N (1) of deoxyguanosine and N (3) of deoxycytidine. No synthesis of a DNA …

Abstract O 6-Methylguanine-DNA methyltransferase (MGMT) is a DNA repair enzyme that
removes the alkyl groups from the O 6 position of guanine and is then degraded via ubiquitin …

Human O 6-alkylguanine-DNA-transferase (hAGT) is a repair protein that provides
protection from mutagenic events caused by O 6-alkylguanine lesions. As this stoichiometric …

Tumor cells often have defects in DNA repair pathways that make them vulnerable to
specific DNA-damaging anticancer agents. The identification of DNA repair defects in tumor …

DNA duplexes containing a directly opposed O4-2′-deoxythymidine-alkyl-O4-2′-
deoxythymidine (O4-dT-alkyl-O4-dT) interstrand cross-link (ICL) have been prepared by the …

O 6-alkylguanine-DNA alkyltransferases (AGT) are responsible for the removal of alkylation
at both the O 6 atom of guanine and O 4 atom of thymine. AGT homologues show vast …