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Advances in mass spectrometry imaging for spatial cancer metabolomics
Mass spectrometry (MS) has become a central technique in cancer research. The ability to
analyze various types of biomolecules in complex biological matrices makes it well suited for …
analyze various types of biomolecules in complex biological matrices makes it well suited for …
Metabolic pathway analysis using stable isotopes in patients with cancer
Metabolic reprogramming is central to malignant transformation and cancer cell growth. How
tumours use nutrients and the relative rates of reprogrammed pathways are areas of intense …
tumours use nutrients and the relative rates of reprogrammed pathways are areas of intense …
Multiplex digital spatial profiling of proteins and RNA in fixed tissue
CR Merritt, GT Ong, SE Church, K Barker… - Nature …, 2020 - nature.com
Abstract Digital Spatial Profiling (DSP) is a method for highly multiplex spatial profiling of
proteins or RNAs suitable for use on formalin-fixed, paraffin-embedded (FFPE) samples. The …
proteins or RNAs suitable for use on formalin-fixed, paraffin-embedded (FFPE) samples. The …
Spatial heterogeneity in the mammalian liver
Hepatocytes operate in highly structured repeating anatomical units termed liver lobules.
Blood flow along the lobule radial axis creates gradients of oxygen, nutrients and hormones …
Blood flow along the lobule radial axis creates gradients of oxygen, nutrients and hormones …
The lichens' microbiota, still a mystery?
M Grimm, M Grube, U Schiefelbein, D Zühlke… - Frontiers in …, 2021 - frontiersin.org
Lichens represent self-supporting symbioses, which occur in a wide range of terrestrial
habitats and which contribute significantly to mineral cycling and energy flow at a global …
habitats and which contribute significantly to mineral cycling and energy flow at a global …
Extracellular matrix as a driver of progressive fibrosis
The extracellular matrix (ECM) is dynamically tuned to optimize physiological function. Its
major properties, including composition and mechanics, profoundly influence cell biology …
major properties, including composition and mechanics, profoundly influence cell biology …
Nutritional value of fish: lipids, proteins, vitamins, and minerals
S Khalili Tilami, S Sampels - Reviews in Fisheries Science & …, 2018 - Taylor & Francis
The present review aims to give a concise review about important nutrients from fish and
their impact on human health. In addition, possible effects of rearing system and feeding on …
their impact on human health. In addition, possible effects of rearing system and feeding on …
Lipid droplets in neurodegenerative disorders
BC Farmer, AE Walsh, JC Kluemper… - Frontiers in …, 2020 - frontiersin.org
Knowledge of lipid droplets (LDs) has evolved from simple depots of lipid storage to
dynamic and functionally active organelles involved in a variety of cellular functions. Studies …
dynamic and functionally active organelles involved in a variety of cellular functions. Studies …
Mass spectrometry approaches to glycomic and glycoproteomic analyses
Glycomic and glycoproteomic analyses involve the characterization of oligosaccharides
(glycans) conjugated to proteins. Glycans are produced through a complicated nontemplate …
(glycans) conjugated to proteins. Glycans are produced through a complicated nontemplate …
Comparing DESI-MSI and MALDI-MSI mediated spatial metabolomics and their applications in cancer studies
Metabolic heterogeneity of cancer contributes significantly to its poor treatment outcomes
and prognosis. As a result, studies continue to focus on identifying new biomarkers and …
and prognosis. As a result, studies continue to focus on identifying new biomarkers and …