Advances in mass spectrometry imaging for spatial cancer metabolomics

X Ma, FM Fernández - Mass spectrometry reviews, 2024 - Wiley Online Library
Mass spectrometry (MS) has become a central technique in cancer research. The ability to
analyze various types of biomolecules in complex biological matrices makes it well suited for …

Metabolic pathway analysis using stable isotopes in patients with cancer

CR Bartman, B Faubert, JD Rabinowitz… - Nature Reviews …, 2023 - nature.com
Metabolic reprogramming is central to malignant transformation and cancer cell growth. How
tumours use nutrients and the relative rates of reprogrammed pathways are areas of intense …

Multiplex digital spatial profiling of proteins and RNA in fixed tissue

CR Merritt, GT Ong, SE Church, K Barker… - Nature …, 2020 - nature.com
Abstract Digital Spatial Profiling (DSP) is a method for highly multiplex spatial profiling of
proteins or RNAs suitable for use on formalin-fixed, paraffin-embedded (FFPE) samples. The …

Spatial heterogeneity in the mammalian liver

S Ben-Moshe, S Itzkovitz - Nature reviews Gastroenterology & …, 2019 - nature.com
Hepatocytes operate in highly structured repeating anatomical units termed liver lobules.
Blood flow along the lobule radial axis creates gradients of oxygen, nutrients and hormones …

The lichens' microbiota, still a mystery?

M Grimm, M Grube, U Schiefelbein, D Zühlke… - Frontiers in …, 2021 - frontiersin.org
Lichens represent self-supporting symbioses, which occur in a wide range of terrestrial
habitats and which contribute significantly to mineral cycling and energy flow at a global …

Extracellular matrix as a driver of progressive fibrosis

J Herrera, CA Henke, PB Bitterman - The Journal of clinical investigation, 2018 - jci.org
The extracellular matrix (ECM) is dynamically tuned to optimize physiological function. Its
major properties, including composition and mechanics, profoundly influence cell biology …

Nutritional value of fish: lipids, proteins, vitamins, and minerals

S Khalili Tilami, S Sampels - Reviews in Fisheries Science & …, 2018 - Taylor & Francis
The present review aims to give a concise review about important nutrients from fish and
their impact on human health. In addition, possible effects of rearing system and feeding on …

Lipid droplets in neurodegenerative disorders

BC Farmer, AE Walsh, JC Kluemper… - Frontiers in …, 2020 - frontiersin.org
Knowledge of lipid droplets (LDs) has evolved from simple depots of lipid storage to
dynamic and functionally active organelles involved in a variety of cellular functions. Studies …

Mass spectrometry approaches to glycomic and glycoproteomic analyses

LR Ruhaak, G Xu, Q Li, E Goonatilleke… - Chemical …, 2018 - ACS Publications
Glycomic and glycoproteomic analyses involve the characterization of oligosaccharides
(glycans) conjugated to proteins. Glycans are produced through a complicated nontemplate …

Comparing DESI-MSI and MALDI-MSI mediated spatial metabolomics and their applications in cancer studies

MJ He, W Pu, X Wang, W Zhang, D Tang… - Frontiers in oncology, 2022 - frontiersin.org
Metabolic heterogeneity of cancer contributes significantly to its poor treatment outcomes
and prognosis. As a result, studies continue to focus on identifying new biomarkers and …