This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Mechanical force is an essential physical element that contributes to the formation and
function of life. The discovery of the evolutionarily conserved PIEZO family, including PIEZO1 …

Piezo1 and Piezo2 are mechanically activated ion channels that mediate touch perception,
proprioception and vascular development. Piezo proteins are distinct from other ion …

Mechanosensation is perhaps the last sensory modality not understood at the molecular
level. Ion channels that sense mechanical force are postulated to play critical roles in a …

Mechanotransduction, the conversion of physical forces into biochemical signals, is
essential for various physiological processes such as the conscious sensations of touch and …

Cellular mechanotransduction, the process of translating mechanical forces into biological
signals, is crucial for a wide range of physiological processes. A role for ion channels in …

Piezo ion channels are activated by various types of mechanical stimuli and function as
biological pressure sensors in both vertebrates and invertebrates. To date, mechanical …

In 2010, two proteins, Piezo1 and Piezo2, were identified as the long-sought molecular
carriers of an excitatory mechanically activated current found in many cells. This discovery …

Red blood cells (RBCs) experience significant mechanical forces while recirculating, but the
consequences of these forces are not fully understood. Recent work has shown that gain-of …

Mechanotransduction couples mechanical stimulation with ion flux, which is critical for
normal biological processes involved in neuronal cell development, pain sensation, and red …