Next-generation sequencing (NGS) technologies using DNA, RNA, or methylation
sequencing have impacted enormously on the life sciences. NGS is the choice for large …

In the last years, mortality from breast cancer has declined in western countries as a
consequence of a more widespread screening resulting in earlier detection, as well as an …

DNA methylation is one of the most important epigenetic mechanisms that governing
regulation of gene expression, aberrant DNA methylation patterns are strongly associated …

High mortality and low survival rates for pancreatic ductal adenocarcinoma (PDAC) mainly
result from the delay in diagnosis and treatment. Therefore, there is an urgent need to …

Neo-Darwinian explanations of organic evolution have settled on mutation as the principal
factor in producing evolutionary novelty. Mechanistic characterizations have been also …

MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression mainly at
the posttranscriptional level. Similar to protein-coding genes, their expression is also …

MicroRNAs (miRNAs) are a class of short non-coding RNAs (ncRNAs) with typical sequence
lengths of 19–25 nucleotides and extraordinary abilities to regulate gene expression …

Long noncoding RNA (lncRNA) plays pivotal roles in cancer development. To date, only a
small number of lncRNAs have been characterized at functional level. Here, we discovered …

The inability to digest lactose, due to lactase nonpersistence, is a common trait in adult
mammals, except in certain human populations that exhibit lactase persistence. It is not …

Scope Reduced expression of tumor suppressor genes (TSG) increases the susceptibility to
breast cancer. However, only a small percentage of breast tumors is related to family history …