Sepsis is a highly lethal and urgent unmet medical need. It is the result of a complex
interplay of several pathways, including inflammation, immune activation, hypoxia, and …

There has been an explosion of interest in the signaling capacity of energy metabolites. A
prime example is the Krebs cycle substrate succinate, an archetypal respiratory substrate …

Multiple organ dysfunction syndrome (MODS) is one of the most common syndromes of
critical illness and the leading cause of mortality among critically ill patients. Multiple organ …

The conversion of skeletal muscle fiber from fast twitch to slow‐twitch is important for
sustained and tonic contractile events, maintenance of energy homeostasis, and the …

The pathogenesis of sepsis and its progression to multiple organ dysfunction syndrome and
septic shock have been the subject of investigations for nearly half a century. Controversies …

Septic shock is characterized by circulatory compromise, microcirculatory alterations and
mitochondrial damage, which all reduce cellular energy production. In order to reduce the …

Sepsis is a dysregulated response to severe infection characterized by life-threatening
organ failure and is the leading cause of mortality worldwide. Multiple organ failure is the …

Sepsis and multiple organ dysfunction syndrome (MODS) are major causes of morbidity and
mortality in the intensive care unit. Recently mitochondrial dysfunction has been proposed …

Sepsis is a complex pathophysiological disorder arising from a systemic inflammatory
response to infection. Patients are clinically classified according to the presence of signs of …

A pivotal role is suggested for mitochondrial dysfunction during the occurrence of multiorgan
failure. Understanding the precise effect of sepsis on the mitochondrial function and the …