Efferocytosis in health and disease
The clearance of apoptotic cells by professional and non-professional phagocytes—a
process termed 'efferocytosis'—is essential for the maintenance of tissue homeostasis …
process termed 'efferocytosis'—is essential for the maintenance of tissue homeostasis …
Inflammation resolution: implications for atherosclerosis
AC Doran - Circulation research, 2022 - Am Heart Assoc
Resolution is an active and highly coordinated process that occurs in response to
inflammation to limit tissue damage and promote repair. When the resolution program fails …
inflammation to limit tissue damage and promote repair. When the resolution program fails …
Myeloid cell PKM2 deletion enhances efferocytosis and reduces atherosclerosis
Background: The glycolytic enzyme PKM2 (pyruvate kinase muscle 2) is upregulated in
monocytes/macrophages of patients with atherosclerotic coronary artery disease. However …
monocytes/macrophages of patients with atherosclerotic coronary artery disease. However …
Crosstalk between macrophages and vascular smooth muscle cells in atherosclerotic plaque stability
A Yurdagul Jr - Arteriosclerosis, thrombosis, and vascular biology, 2022 - Am Heart Assoc
Most acute cardiovascular events are due to plaque rupture, with atheromas containing
large necrotic cores and thin fibrous caps being more susceptible to rupture and lesions with …
large necrotic cores and thin fibrous caps being more susceptible to rupture and lesions with …
Lipid droplets sequester palmitic acid to disrupt endothelial ciliation and exacerbate atherosclerosis in male mice
Y Tan, Z Huang, Y **, J Wang, H Fan, Y Liu… - Nature …, 2024 - nature.com
Disruption of ciliary homeostasis in vascular endothelial cells has been implicated in the
development of atherosclerosis. However, the molecular basis for the regulation of …
development of atherosclerosis. However, the molecular basis for the regulation of …
SARS-CoV-2 RNA elements share human sequence identity and upregulate hyaluronan via NamiRNA-enhancer network
W Li, S Yang, P Xu, D Zhang, Y Tong, L Chen, B Jia… - …, 2022 - thelancet.com
Summary Background Since late 2019, SARS-CoV-2 infection has resulted in COVID-19
accompanied by diverse clinical manifestations. However, the underlying mechanism of how …
accompanied by diverse clinical manifestations. However, the underlying mechanism of how …
Epsin nanotherapy regulates cholesterol transport to fortify atheroma regression
Background: Excess cholesterol accumulation in lesional macrophages elicits complex
responses in atherosclerosis. Epsins, a family of endocytic adaptors, fuel the progression of …
responses in atherosclerosis. Epsins, a family of endocytic adaptors, fuel the progression of …
Potential mechanisms and effects of efferocytosis in atherosclerosis
L Wang, H Li, Y Tang, P Yao - Frontiers in endocrinology, 2021 - frontiersin.org
Atherosclerosis (AS) is the main pathological basis for the development of cardio-
cerebrovascular diseases. Abnormal accumulation of apoptotic and necrotic cells resulted in …
cerebrovascular diseases. Abnormal accumulation of apoptotic and necrotic cells resulted in …
Targeting epsins to inhibit fibroblast growth factor signaling while potentiating transforming growth factor-β signaling constrains endothelial-to-mesenchymal transition …
Background: Epsin endocytic adaptor proteins are implicated in the progression of
atherosclerosis; however, the underlying molecular mechanisms have not yet been fully …
atherosclerosis; however, the underlying molecular mechanisms have not yet been fully …
CNP ameliorates macrophage inflammatory response and atherosclerosis
Q Bao, B Zhang, L Zhou, Q Yang, X Mu, X Liu… - Circulation …, 2024 - Am Heart Assoc
BACKGROUND: CNP (C-type natriuretic peptide), an endogenous short peptide in the
natriuretic peptide family, has emerged as an important regulator to govern vascular …
natriuretic peptide family, has emerged as an important regulator to govern vascular …