Diffuse large B-cell lymphoma

LH Sehn, G Salles - New England Journal of Medicine, 2021 - Mass Medical Soc
Diffuse Large B-Cell Lymphoma DLBCL, an aggressive cancer, accounts for about 30% of
all lymphomas. Empirical combination chemotherapy cures about 65% of patients initially …

Prevention and management of secondary central nervous system lymphoma

S Bobillo, J Khwaja, AJM Ferreri… - Haematologica, 2022 - pmc.ncbi.nlm.nih.gov
Secondary central nervous system (CNS) lymphoma (SCNSL) is defined by the involvement
of the CNS, either at the time of initial diagnosis of systemic lymphoma or in the setting of …

Diffuse large B-cell lymphoma (DLBCL): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

H Tilly, MG Da Silva, U Vitolo, A Jack… - Annals of …, 2015 - annalsofoncology.org
Diffuse large B-cell lymphoma (DLBCL) constitutes 30%–58% of non-Hodgkin's lymphoma
series. The crude incidence in Europe is 3.8/100 000/year [1]. The incidence increases with …

CNS international prognostic index: a risk model for CNS relapse in patients with diffuse large B-cell lymphoma treated with R-CHOP

N Schmitz, S Zeynalova, M Nickelsen… - Journal of Clinical …, 2016 - ascopubs.org
Purpose To develop and validate a risk score for relapse in the CNS in patients with diffuse
large B-cell lymphoma (DLBCL). Patients and Methods A total of 2,164 patients (18 to 80 …

Revised adult T-cell leukemia-lymphoma international consensus meeting report

LB Cook, S Fuji, O Hermine, A Bazarbachi… - Journal of Clinical …, 2019 - ascopubs.org
Purpose Adult T-cell leukemia-lymphoma (ATL) is a distinct mature T-cell malignancy
caused by chronic infection with human T-lymphotropic virus type 1 with diverse clinical …

Single-route CNS prophylaxis for aggressive non-Hodgkin lymphomas: real-world outcomes from 21 US academic institutions

VM Orellana-Noia, DR Reed… - Blood, The Journal …, 2022 - ashpublications.org
Prophylaxis is commonly used to prevent central nervous sy stem (CNS) relapse in diffuse
large B-cell lymphoma (DLBCL), with no clear standard of care. We retrospectively …

Impact of dual expression of MYC and BCL2 by immunohistochemistry on the risk of CNS relapse in DLBCL

KJ Savage, GW Slack, A Mottok… - Blood, The Journal …, 2016 - ashpublications.org
Dual expression of MYC and BCL2 by immunohistochemistry (IHC) is associated with poor
outcome in diffuse large B-cell lymphoma (DLBCL). Dual translocation of MYC and BCL2, so …

How I treat double-hit lymphoma

JW Friedberg - Blood, The Journal of the American Society of …, 2017 - ashpublications.org
The 2016 revision of the World Health Organization (WHO) classification for lymphoma has
included a new category of lymphoma, separate from diffuse large B-cell lymphoma, termed …

Ineffectiveness of high‐dose methotrexate for prevention of CNS relapse in diffuse large B‐cell lymphoma

R Puckrin, H El Darsa, S Ghosh… - American journal of …, 2021 - Wiley Online Library
Central nervous system (CNS) relapse affects 5% of diffuse large B‐cell lymphoma (DLBCL)
patients and portends a poor prognosis. Prophylactic intravenous high‐dose methotrexate …

Prophylaxis with intrathecal or high-dose methotrexate in diffuse large B-cell lymphoma and high risk of CNS relapse

S Bobillo, E Joffe, D Sermer, P Mondello… - Blood cancer …, 2021 - nature.com
Although methotrexate (MTX) is the most widely used therapy for central nervous system
(CNS) prophylaxis in patients with diffuse large B-cell lymphoma (DLBCL), the optimal …