[HTML][HTML] TP53 mutations in epithelial ovarian cancer
Y Zhang, L Cao, D Nguyen, H Lu - Translational cancer research, 2016 - ncbi.nlm.nih.gov
Genomic sequencing analyses of a variety of human cancers have revealed that massive
mutations of cancer-relevant genes are the major alterations in cancerous cells, and their …
mutations of cancer-relevant genes are the major alterations in cancerous cells, and their …
The p53 tumor suppressor: a master regulator of diverse cellular processes and therapeutic target in cancer
M Farnebo, VJN Bykov, KG Wiman - Biochemical and biophysical research …, 2010 - Elsevier
The tumor suppressor p53 has been implicated in a growing number of biological
processes, including cell cycle arrest, senescence, apoptosis, autophagy, metabolism, and …
processes, including cell cycle arrest, senescence, apoptosis, autophagy, metabolism, and …
p63 protects the female germ line during meiotic arrest
Meiosis in the female germ line of mammals is distinguished by a prolonged arrest in
prophase of meiosis I between homologous chromosome recombination and ovulation. How …
prophase of meiosis I between homologous chromosome recombination and ovulation. How …
Mutant p53: an oncogenic transcription factor
S Strano, S Dell'Orso, S Di Agostino, G Fontemaggi… - Oncogene, 2007 - nature.com
Inactivation of tumor-suppressor genes is one of the key hallmarks of a tumor. Unlike other
tumor-suppressor genes, p53 is inactivated by missense mutations in half of all human …
tumor-suppressor genes, p53 is inactivated by missense mutations in half of all human …
Quaternary structures of tumor suppressor p53 and a specific p53–DNA complex
The homotetrameric tumor suppressor p53 consists of folded core and tetramerization
domains, linked and flanked by intrinsically disordered segments that impede structure …
domains, linked and flanked by intrinsically disordered segments that impede structure …
Mutational spectra of human cancer
The purpose of this review is to summarize the evidence that can be used to reconstruct the
etiology of human cancers from mutations found in tumors. Mutational spectra of the tumor …
etiology of human cancers from mutations found in tumors. Mutational spectra of the tumor …
Pharmacological reactivation of mutant p53: from protein structure to the cancer patient
KG Wiman - Oncogene, 2010 - nature.com
The p53 tumor suppressor pathway blocks tumor development by triggering apoptosis or
cellular senescence in response to oncogenic stress. A large fraction of human tumors carry …
cellular senescence in response to oncogenic stress. A large fraction of human tumors carry …
Hdmx modulates the outcome of p53 activation in human tumor cells
Tumors that express wild-type P53 provide a target for therapies designed to reactivate P53
function. This is supported by the potent activation of P53 in tumor cells by Nutlin, a cis …
function. This is supported by the potent activation of P53 in tumor cells by Nutlin, a cis …
Safety and efficacy in advanced solid tumors of a targeted nanocomplex carrying the p53 gene used in combination with docetaxel: a phase 1b study
KF Pirollo, J Nemunaitis, PK Leung, R Nunan… - Molecular Therapy, 2016 - cell.com
Loss of p53 suppressor function, through mutations or inactivation of the p53 pathway,
occurs in most human cancers. SGT-53 is a liposomal nanocomplex designed for systemic …
occurs in most human cancers. SGT-53 is a liposomal nanocomplex designed for systemic …
Cancer chemoprevention by resveratrol: The p53 tumor suppressor protein as a promising molecular target
Increasing epidemiological and experimental evidence has demonstrated an inverse
relationship between the consumption of plant foods and the incidence of chronic diseases …
relationship between the consumption of plant foods and the incidence of chronic diseases …