Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) has
been developed and employed in multiple clinical imaging research centers worldwide …

Cancer cells are characterized by a metabolic shift in cellular energy production,
orchestrated by the transcription factor HIF-1α, from mitochondrial oxidative phosphorylation …

Tumor microenvironments can promote stem cell maintenance, tumor growth, and
therapeutic resistance, findings linked by the tumor-initiating cell hypothesis. Standard of …

Abnormal pH is a common feature of malignant tumors and has been associated clinically
with suboptimal outcomes. Amide proton transfer magnetic resonance imaging (APT MRI) …

Altered metabolism is considered a core hallmark of cancer. By monitoring in vivo
metabolites changes or characterizing the tumor microenvironment, non-invasive imaging …

Simple Summary Glioblastoma is a rapidly progressing brain cancer that is very difficult to
treat. Given that many aspects of cell and tissue behavior are controlled by electric signaling …

Carbonic anhydrases (CAs) are zinc-containing metalloenzymes that participate in the
regulation of pH homeostasis in addition to many other important physiological functions …

Purpose Extracellular pH (pHe) is an important biomarker for cancer cell metabolism. Acido‐
chemical exchange saturation transfer (CEST) MRI uses the contrast agent iopamidol to …

Dichloroacetate (DCA) can reverse the glycolytic phenotype that is responsible of increased
lactate production and extracellular pH acidification in cancer cells. Magnetic resonance …

Functional and molecular MRI techniques are capable of measuring biologic properties of
tumor tissue. Knowledge of these biological properties may improve radiation treatment by …