Wall shear stress and its role in atherosclerosis

M Zhou, Y Yu, R Chen, X Liu, Y Hu, Z Ma… - Frontiers in …, 2023 - frontiersin.org
Atherosclerosis (AS) is the major form of cardiovascular disease and the leading cause of
morbidity and mortality in countries around the world. Atherosclerosis combines the …

[HTML][HTML] Animal models of atherosclerosis

BE Veseli, P Perrotta, GRA De Meyer, L Roth… - European journal of …, 2017 - Elsevier
An ideal animal model of atherosclerosis resembles human anatomy and pathophysiology
and has the potential to be used in medical and pharmaceutical research to obtain results …

Multicentre, randomized comparison of two-stent and provisional stenting techniques in patients with complex coronary bifurcation lesions: the DEFINITION II trial

JJ Zhang, F Ye, K Xu, J Kan, L Tao… - European Heart …, 2020 - academic.oup.com
Aim The present study aimed to assess the benefits of two-stent techniques for patients with
DEFINITION criteria-defined complex coronary bifurcation lesions. Methods and results In …

Effects of shear stress on endothelial cells: go with the flow

DA Chistiakov, AN Orekhov, YV Bobryshev - Acta physiologica, 2017 - Wiley Online Library
Haemodynamic forces influence the functional properties of vascular endothelium.
Endothelial cells (ECs) have a variety of receptors, which sense flow and transmit …

Molecular biology of atherosclerosis

PN Hopkins - Physiological reviews, 2013 - journals.physiology.org
At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Shear-dependent platelet aggregation: mechanisms and therapeutic opportunities

A Rana, E Westein, B Niego… - Frontiers in cardiovascular …, 2019 - frontiersin.org
Cardiovascular diseases (CVD) are the number one cause of morbidity and death
worldwide. As estimated by the WHO, the global death rate from CVD is 31% wherein, a …

Pathology of the vulnerable plaque

R Virmani, AP Burke, A Farb, FD Kolodgie - Journal of the American …, 2006 - jacc.org
The majority of patients with acute coronary syndromes (ACS) present with unstable angina,
acute myocardial infarction, and sudden coronary death. The most common cause of …

Comprehensive plaque assessment by coronary CT angiography

P Maurovich-Horvat, M Ferencik, S Voros… - Nature Reviews …, 2014 - nature.com
Most acute coronary syndromes are caused by sudden luminal thrombosis due to
atherosclerotic plaque rupture or erosion. Preventing such an event seems to be the only …

Pathophysiologic mechanisms of acute ischemic stroke: An overview with emphasis on therapeutic significance beyond thrombolysis

P Deb, S Sharma, KM Hassan - Pathophysiology, 2010 - Elsevier
Stroke is a serious neurological disease, and constitutes a major cause of death and
disability throughout the world. The pathophysiology of stroke is complex, and involves …

Endothelial shear stress in the evolution of coronary atherosclerotic plaque and vascular remodelling: current understanding and remaining questions

JJ Wentzel, YS Chatzizisis, FJH Gijsen… - Cardiovascular …, 2012 - academic.oup.com
The heterogeneity of plaque formation, the vascular remodelling response to plaque
formation, and the consequent phenotype of plaque instability attest to the extraordinarily …