Challenges in the diagnosis of Parkinson's disease

E Tolosa, A Garrido, SW Scholz, W Poewe - The Lancet Neurology, 2021‏ - thelancet.com
Parkinson's disease is the second most common neurodegenerative disease and its
prevalence has been projected to double over the next 30 years. An accurate diagnosis of …

Are dementia with Lewy bodies and Parkinson's disease dementia the same disease?

KA Jellinger, AD Korczyn - Advances in Surgical and Medical …, 2023‏ - taylorfrancis.com
The clinical features of dementia with Lewy bodies (DLB) and Parkinson's disease dementia
(PDD) are similar and include dementia, cognitive fluctuations, and (visual) hallucinations in …

Dementia with Lewy bodies and Parkinson's disease-dementia: current concepts and controversies

KA Jellinger - Journal of neural transmission, 2018‏ - Springer
Dementia with Lewy bodies (DLB) and Parkinson's disease-dementia (PDD), although
sharing many clinical, neurochemical and morphological features, according to DSM-5, are …

The role of neuroimaging in Parkinson's disease

NSR Bidesi, I Vang Andersen… - Journal of …, 2021‏ - Wiley Online Library
Parkinson's disease (PD) is a neurodegenerative disorder that affects millions of people
worldwide. Two hallmarks of PD are the accumulation of alpha‐synuclein and the loss of …

Molecular imaging: design mechanism and bioapplications

L Chen, Y Lyu, X Zhang, L Zheng, Q Li, D Ding… - Science China …, 2023‏ - Springer
Molecular imaging is a non-invasive method to image and analyze the concentration and
activity of functional biomolecules in cells or in vivo at molecular level, and plays an …

Natural history of motor symptoms in Parkinson's disease and the long-duration response to levodopa

R Cilia, E Cereda, A Akpalu, FS Sarfo, M Cham… - Brain, 2020‏ - academic.oup.com
The natural pattern of progression of Parkinson's disease is largely unknown because
patients are conventionally followed on treatment. As Parkinson's disease progresses, the …

In vivo cholinergic basal forebrain atrophy predicts cognitive decline in de novo Parkinson's disease

NJ Ray, S Bradburn, C Murgatroyd, U Toseeb, P Mir… - Brain, 2018‏ - academic.oup.com
Abstract See Gratwicke and Foltynie (doi: 10.1093/brain/awx333) for a scientific commentary
on this article. Cognitive impairments are a prevalent and disabling non-motor complication …

Network imaging biomarkers: insights and clinical applications in Parkinson's disease

KA Schindlbeck, D Eidelberg - The Lancet Neurology, 2018‏ - thelancet.com
Parkinson's disease presents several practical challenges: it can be difficult to distinguish
from atypical parkinsonian syndromes, clinical ratings can be insensitive as markers of …

Diagnostic biomarkers for Parkinson's disease at a glance: where are we?

I Cova, A Priori - Journal of Neural Transmission, 2018‏ - Springer
Parkinson's disease (PD) is a neurodegenerative disorder whose aetiology remains unclear:
degeneration involves several neurotransmission systems, resulting in a heterogeneous …

Retinal thinning associates with nigral dopaminergic loss in de novo Parkinson disease

J Ahn, JY Lee, TW Kim, EJ Yoon, S Oh, YK Kim, JM Kim… - Neurology, 2018‏ - neurology.org
Objective To analyze the relationship between retinal thinning and nigral dopaminergic loss
in de novo Parkinson disease (PD). Methods Forty-nine patients with PD and 54 age …