Cochlear implants provide effective auditory rehabilitation for patients with severe to
profound sensorineural hearing loss. Recent advances in cochlear implant technology and …

In 2010 Cochlear initiated a coordinated preclinical research program to identify the factors
and underlying mechanisms of acoustic hearing loss following cochlear implantation and …

Hearing impairment is the most common sensory deficit. It is frequently caused by the
expression of an allele carrying a single dominant missense mutation. Herein, we show that …

Intratympanic (IT) therapies have been explored to address several side effects that could be
caused by systemic administration of steroids to treat inner ear diseases. For effective drug …

Hereditary hearing loss is a clinically and genetically heterogeneous disorder. More than 80
genes have been implicated to date, and with the advent of targeted genomic enrichment …

Objectives Cochlear implants provide an effective treatment option for those with severe
hearing loss, including those with preserved low frequency hearing. However, certain issues …

Primary cilia are microtubule-based organelles present on most cells that regulate many
physiological processes, ranging from maintaining energy homeostasis to renal function …

Mice with chronic cochlear implants can significantly contribute to our understanding of the
relationship between cochlear health and implant function because of the availability of …

Cochlear implants are neuroprosthetic devices that provide hearing to deaf patients,
although outcomes are highly variable even with prolonged training and use. The central …

Objectives: To model the contribution of implant material and insertion trauma on loss of
acoustic hearing after cochlear implantation in an appropriate animal model. Methods: Sixty …