Exosomal circRNAs: biogenesis, effect and application in human diseases

Y Wang, J Liu, J Ma, T Sun, Q Zhou, W Wang, G Wang… - Molecular cancer, 2019 - Springer
Exosomes have emerged as critical mediators of intercellular communication, both locally
and systemically, by regulating a diverse range of biological processes between cells …

The biology and function of extracellular vesicles in cancer development

X Zhang, D Liu, Y Gao, C Lin, Q An, Y Feng… - Frontiers in Cell and …, 2021 - frontiersin.org
Extracellular vesicles (EVs) exert their biological functions by delivering proteins,
metabolites, and nucleic acids to recipient cells. EVs play important roles in cancer …

Exosomal circRNA_100284 from arsenite-transformed cells, via microRNA-217 regulation of EZH2, is involved in the malignant transformation of human hepatic cells …

X Dai, C Chen, Q Yang, J Xue, X Chen, B Sun… - Cell death & …, 2018 - nature.com
Intercellular communication between malignant cells and neighboring nonmalignant cells is
involved in carcinogenesis. In the progression of carcinogenesis, exosomes are …

Cell-free tumor DNA in blood plasma as a marker for circulating tumor cells in prostate cancer

H Schwarzenbach, C Alix-Panabieres… - Clinical Cancer …, 2009 - aacrjournals.org
Purpose: Circulating cell-free DNA in the blood of cancer patients harbors tumor-specific
aberrations. Here, we investigated whether this DNA might also reflect the presence of …

The inhibition of the highly expressed miR-221 and miR-222 impairs the growth of prostate carcinoma xenografts in mice

N Mercatelli, V Coppola, D Bonci, F Miele, A Costantini… - PloS one, 2008 - journals.plos.org
Background MiR-221 and miR-222 are two highly homologous microRNAs whose
upregulation has been recently described in several types of human tumors, for some of …

The serine/threonine protein kinase, p90 ribosomal S6 kinase, is an important regulator of prostate cancer cell proliferation

DE Clark, TM Errington, JA Smith, HF Frierson Jr… - Cancer …, 2005 - aacrjournals.org
An increase in the activity of mitogen-activated protein kinase (MAPK) has been correlated
with the progression of prostate cancer to advanced disease in humans. The …

Mechanisms of action of novel agents for prostate cancer chemoprevention

RP Singh, R Agarwal - Endocrine-related cancer, 2006 - erc.bioscientifica.com
Despite advances in the understanding of prostate cancer (PCa) growth and development, it
is still the leading incidence of cases and the second leading cause of mortality due to …

Beneficial effects of tea and its polyphenols against prostate cancer

IA Siddiqui, VM Adhami, M Saleem… - Molecular nutrition & …, 2006 - Wiley Online Library
Tea, next to water, is the most widely consumed beverage in the world. Depending upon the
level of fermentation, tea can be categorized into three types: green (unfermented), oolong …

High-grade neuroendocrine carcinoma of the ampulla of Vater: a clinicopathologic and immunohistochemical analysis of 14 cases

H Nassar, J Albores-Saavedra… - The American journal of …, 2005 - journals.lww.com
We describe the clinical and pathologic features of 14 cases of high-grade neuroendocrine
carcinoma (HGNEC) of the ampulla of Vater classified according to WHO classification of …

Epigenetic silencing of miR-218 by the lncRNA CCAT1, acting via BMI1, promotes an altered cell cycle transition in the malignant transformation of HBE cells induced …

L Lu, H Xu, F Luo, X Liu, X Lu, Q Yang, J Xue… - Toxicology and applied …, 2016 - Elsevier
Cigarette smoking is the strongest risk factor for the development of lung cancer, the leading
cause of cancer-related deaths. However, the molecular mechanisms leading to lung cancer …