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Exosomal circRNAs: biogenesis, effect and application in human diseases
Exosomes have emerged as critical mediators of intercellular communication, both locally
and systemically, by regulating a diverse range of biological processes between cells …
and systemically, by regulating a diverse range of biological processes between cells …
The biology and function of extracellular vesicles in cancer development
X Zhang, D Liu, Y Gao, C Lin, Q An, Y Feng… - Frontiers in Cell and …, 2021 - frontiersin.org
Extracellular vesicles (EVs) exert their biological functions by delivering proteins,
metabolites, and nucleic acids to recipient cells. EVs play important roles in cancer …
metabolites, and nucleic acids to recipient cells. EVs play important roles in cancer …
Exosomal circRNA_100284 from arsenite-transformed cells, via microRNA-217 regulation of EZH2, is involved in the malignant transformation of human hepatic cells …
X Dai, C Chen, Q Yang, J Xue, X Chen, B Sun… - Cell death & …, 2018 - nature.com
Intercellular communication between malignant cells and neighboring nonmalignant cells is
involved in carcinogenesis. In the progression of carcinogenesis, exosomes are …
involved in carcinogenesis. In the progression of carcinogenesis, exosomes are …
Cell-free tumor DNA in blood plasma as a marker for circulating tumor cells in prostate cancer
H Schwarzenbach, C Alix-Panabieres… - Clinical Cancer …, 2009 - aacrjournals.org
Purpose: Circulating cell-free DNA in the blood of cancer patients harbors tumor-specific
aberrations. Here, we investigated whether this DNA might also reflect the presence of …
aberrations. Here, we investigated whether this DNA might also reflect the presence of …
The inhibition of the highly expressed miR-221 and miR-222 impairs the growth of prostate carcinoma xenografts in mice
N Mercatelli, V Coppola, D Bonci, F Miele, A Costantini… - PloS one, 2008 - journals.plos.org
Background MiR-221 and miR-222 are two highly homologous microRNAs whose
upregulation has been recently described in several types of human tumors, for some of …
upregulation has been recently described in several types of human tumors, for some of …
The serine/threonine protein kinase, p90 ribosomal S6 kinase, is an important regulator of prostate cancer cell proliferation
DE Clark, TM Errington, JA Smith, HF Frierson Jr… - Cancer …, 2005 - aacrjournals.org
An increase in the activity of mitogen-activated protein kinase (MAPK) has been correlated
with the progression of prostate cancer to advanced disease in humans. The …
with the progression of prostate cancer to advanced disease in humans. The …
Mechanisms of action of novel agents for prostate cancer chemoprevention
RP Singh, R Agarwal - Endocrine-related cancer, 2006 - erc.bioscientifica.com
Despite advances in the understanding of prostate cancer (PCa) growth and development, it
is still the leading incidence of cases and the second leading cause of mortality due to …
is still the leading incidence of cases and the second leading cause of mortality due to …
Beneficial effects of tea and its polyphenols against prostate cancer
Tea, next to water, is the most widely consumed beverage in the world. Depending upon the
level of fermentation, tea can be categorized into three types: green (unfermented), oolong …
level of fermentation, tea can be categorized into three types: green (unfermented), oolong …
High-grade neuroendocrine carcinoma of the ampulla of Vater: a clinicopathologic and immunohistochemical analysis of 14 cases
H Nassar, J Albores-Saavedra… - The American journal of …, 2005 - journals.lww.com
We describe the clinical and pathologic features of 14 cases of high-grade neuroendocrine
carcinoma (HGNEC) of the ampulla of Vater classified according to WHO classification of …
carcinoma (HGNEC) of the ampulla of Vater classified according to WHO classification of …
Epigenetic silencing of miR-218 by the lncRNA CCAT1, acting via BMI1, promotes an altered cell cycle transition in the malignant transformation of HBE cells induced …
L Lu, H Xu, F Luo, X Liu, X Lu, Q Yang, J Xue… - Toxicology and applied …, 2016 - Elsevier
Cigarette smoking is the strongest risk factor for the development of lung cancer, the leading
cause of cancer-related deaths. However, the molecular mechanisms leading to lung cancer …
cause of cancer-related deaths. However, the molecular mechanisms leading to lung cancer …