[HTML][HTML] Nanoparticle-mediated brain drug delivery: Overcoming blood–brain barrier to treat neurodegenerative diseases
The blood–brain barrier (BBB) is a vital boundary between neural tissue and circulating
blood. The BBB's unique and protective features control brain homeostasis as well as ion …
blood. The BBB's unique and protective features control brain homeostasis as well as ion …
Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles
The application of nanomedicines is increasing rapidly with the promise of targeted and
efficient drug delivery. Nanomedicines address the shortcomings of conventional therapy, as …
efficient drug delivery. Nanomedicines address the shortcomings of conventional therapy, as …
Development of polymeric nanoparticles for blood–brain barrier transfer—strategies and challenges
Neurological disorders such as Alzheimer's disease, stroke, and brain cancers are difficult to
treat with current drugs as their delivery efficacy to the brain is severely hampered by the …
treat with current drugs as their delivery efficacy to the brain is severely hampered by the …
Transport of drugs across the blood–brain barrier by nanoparticles
S Wohlfart, S Gelperina, J Kreuter - Journal of controlled release, 2012 - Elsevier
The central nervous system is well protected by the blood–brain barrier (BBB) which
maintains its homeostasis. Due to this barrier many potential drugs for the treatment of …
maintains its homeostasis. Due to this barrier many potential drugs for the treatment of …
Nanotechnology: a promising approach for delivery of neuroprotective drugs
Central nervous system (CNS) disorders especially neurodegenerative disorders are the
major challenge for public health and demand the great attention of researchers to protect …
major challenge for public health and demand the great attention of researchers to protect …
Drug delivery to the central nervous system by polymeric nanoparticles: what do we know?
J Kreuter - Advanced drug delivery reviews, 2014 - Elsevier
Nanoparticles enable the delivery of a great variety of drugs including anticancer drugs,
analgesics, anti-Alzheimer's drugs, cardiovascular drugs, protease inhibitors, and several …
analgesics, anti-Alzheimer's drugs, cardiovascular drugs, protease inhibitors, and several …
Overcoming the blood–brain barrier. challenges and tricks for CNS drug delivery
LA Bors, F Erdő - Scientia Pharmaceutica, 2019 - mdpi.com
Treatment of certain central nervous system disorders, including different types of cerebral
malignancies, is limited by traditional oral or systemic administrations of therapeutic drugs …
malignancies, is limited by traditional oral or systemic administrations of therapeutic drugs …
[HTML][HTML] Advances in develo** therapeutic strategies for Alzheimer's disease
Alzheimer's disease (AD) is a progressive deterioration of brain function, initially
characterized by cognitive deficits, with loss of recent memory and language ability …
characterized by cognitive deficits, with loss of recent memory and language ability …
From adsorption to covalent bonding: Apolipoprotein E functionalization of polymeric nanoparticles for drug delivery across the blood–brain barrier
The blood–brain barrier (BBB) is composed of brain endothelial cells, pericytes, and
astrocytes, which build a tight cellular barrier. Therapeutic (macro) molecules are not able to …
astrocytes, which build a tight cellular barrier. Therapeutic (macro) molecules are not able to …
Size, surface charge, and shape determine therapeutic effects of nanoparticles on brain and retinal diseases
Nanoparticles can be valuable therapeutic options to overcome physical barriers to reach
central nervous system. Systemically administered nanoparticles can pass through blood …
central nervous system. Systemically administered nanoparticles can pass through blood …