Origin, virological features, immune evasion and intervention of SARS-CoV-2 Omicron sublineages

S **a, L Wang, Y Zhu, L Lu, S Jiang - Signal Transduction and Targeted …, 2022 - nature.com
Recently, a large number of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) variants continuously emerged and posed a major threat to global public health. Among …

[HTML][HTML] A critical analysis of the use of cilgavimab plus tixagevimab monoclonal antibody cocktail (Evusheld™) for COVID-19 prophylaxis and treatment

D Focosi, A Casadevall - Viruses, 2022 - mdpi.com
Evusheld®(tixagevimab+ cilgavimab; AZD7442) was the first anti-Spike monoclonal
antibody (mAb) cocktail designed not only for treatment but also with pre-exposure …

BA. 2.12. 1, BA. 4 and BA. 5 escape antibodies elicited by Omicron infection

Y Cao, A Yisimayi, F Jian, W Song, T **ao, L Wang… - Nature, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages BA.
2.12. 1, BA. 4 and BA. 5 exhibit higher transmissibility than the BA. 2 lineage. The receptor …

Omicron BA. 4/BA. 5 escape neutralizing immunity elicited by BA. 1 infection

K Khan, F Karim, Y Ganga, M Bernstein, Z Jule… - Nature …, 2022 - nature.com
Abstract SARS-CoV-2 Omicron (B. 1.1. 529) BA. 4 and BA. 5 sub-lineages, first detected in
South Africa, have changes relative to Omicron BA. 1 including substitutions in the spike …

Clinical severity of SARS-CoV-2 Omicron BA. 4 and BA. 5 lineages compared to BA. 1 and Delta in South Africa

N Wolter, W Jassat, S Walaza, R Welch… - Nature …, 2022 - nature.com
Omicron lineages BA. 4 and BA. 5 drove a fifth wave of COVID-19 cases in South Africa.
Here, we use the presence/absence of the S-gene target as a proxy for SARS-CoV-2 …

Spike mutations contributing to the altered entry preference of SARS-CoV-2 omicron BA. 1 and BA. 2

B Hu, JFW Chan, H Liu, Y Liu, Y Chai… - Emerging Microbes & …, 2022 - Taylor & Francis
ABSTRACT SARS-CoV-2 B. 1.1. 529.1 (Omicron BA. 1) emerged in November 2021 and
quickly became the predominant circulating SARS-CoV-2 variant globally. Omicron BA. 1 …

Rapid assembly of SARS-CoV-2 genomes reveals attenuation of the Omicron BA. 1 variant through NSP6

TY Taha, IP Chen, JM Hayashi, T Tabata… - Nature …, 2023 - nature.com
Abstract Although the SARS-CoV-2 Omicron variant (BA. 1) spread rapidly across the world
and effectively evaded immune responses, its viral fitness in cell and animal models was …

The Omicron variant of concern: Diversification and convergent evolution in spike protein, and escape from anti-Spike monoclonal antibodies

D Focosi, S McConnell, A Casadevall - Drug Resistance Updates, 2022 - Elsevier
Abstract WHO-defined SARS-CoV-2 variants of concern (VOC) drive therapeutics and
vaccine development. The Omicron VOC is dominating the arena since November 2021, but …

An update on the anti-spike monoclonal antibody pipeline for SARS-CoV-2

D Focosi, M Franchini, A Casadevall, F Maggi - Clinical Microbiology and …, 2024 - Elsevier
Abstract Background Anti-Spike monoclonal antibodies represent one of the most tolerable
prophylaxis and therapies for COVID-19 in frail and immunocompromised patients …

Pathogenicity of SARS-CoV-2 Omicron (R346K) variant in Syrian hamsters and its cross-neutralization with different variants of concern

S Mohandas, PD Yadav, G Sapkal, AM Shete… - …, 2022 - thelancet.com
Summary Background SARS-CoV-2 Omicron variant is rampantly spreading across the
globe. We assessed the pathogenicity and immune response generated by BA. 1.1 sub …