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Origin, virological features, immune evasion and intervention of SARS-CoV-2 Omicron sublineages
Recently, a large number of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) variants continuously emerged and posed a major threat to global public health. Among …
2) variants continuously emerged and posed a major threat to global public health. Among …
[HTML][HTML] A critical analysis of the use of cilgavimab plus tixagevimab monoclonal antibody cocktail (Evusheld™) for COVID-19 prophylaxis and treatment
Evusheld®(tixagevimab+ cilgavimab; AZD7442) was the first anti-Spike monoclonal
antibody (mAb) cocktail designed not only for treatment but also with pre-exposure …
antibody (mAb) cocktail designed not only for treatment but also with pre-exposure …
BA. 2.12. 1, BA. 4 and BA. 5 escape antibodies elicited by Omicron infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages BA.
2.12. 1, BA. 4 and BA. 5 exhibit higher transmissibility than the BA. 2 lineage. The receptor …
2.12. 1, BA. 4 and BA. 5 exhibit higher transmissibility than the BA. 2 lineage. The receptor …
Omicron BA. 4/BA. 5 escape neutralizing immunity elicited by BA. 1 infection
Abstract SARS-CoV-2 Omicron (B. 1.1. 529) BA. 4 and BA. 5 sub-lineages, first detected in
South Africa, have changes relative to Omicron BA. 1 including substitutions in the spike …
South Africa, have changes relative to Omicron BA. 1 including substitutions in the spike …
Clinical severity of SARS-CoV-2 Omicron BA. 4 and BA. 5 lineages compared to BA. 1 and Delta in South Africa
Omicron lineages BA. 4 and BA. 5 drove a fifth wave of COVID-19 cases in South Africa.
Here, we use the presence/absence of the S-gene target as a proxy for SARS-CoV-2 …
Here, we use the presence/absence of the S-gene target as a proxy for SARS-CoV-2 …
Spike mutations contributing to the altered entry preference of SARS-CoV-2 omicron BA. 1 and BA. 2
ABSTRACT SARS-CoV-2 B. 1.1. 529.1 (Omicron BA. 1) emerged in November 2021 and
quickly became the predominant circulating SARS-CoV-2 variant globally. Omicron BA. 1 …
quickly became the predominant circulating SARS-CoV-2 variant globally. Omicron BA. 1 …
Rapid assembly of SARS-CoV-2 genomes reveals attenuation of the Omicron BA. 1 variant through NSP6
Abstract Although the SARS-CoV-2 Omicron variant (BA. 1) spread rapidly across the world
and effectively evaded immune responses, its viral fitness in cell and animal models was …
and effectively evaded immune responses, its viral fitness in cell and animal models was …
The Omicron variant of concern: Diversification and convergent evolution in spike protein, and escape from anti-Spike monoclonal antibodies
Abstract WHO-defined SARS-CoV-2 variants of concern (VOC) drive therapeutics and
vaccine development. The Omicron VOC is dominating the arena since November 2021, but …
vaccine development. The Omicron VOC is dominating the arena since November 2021, but …
An update on the anti-spike monoclonal antibody pipeline for SARS-CoV-2
Abstract Background Anti-Spike monoclonal antibodies represent one of the most tolerable
prophylaxis and therapies for COVID-19 in frail and immunocompromised patients …
prophylaxis and therapies for COVID-19 in frail and immunocompromised patients …
Pathogenicity of SARS-CoV-2 Omicron (R346K) variant in Syrian hamsters and its cross-neutralization with different variants of concern
Summary Background SARS-CoV-2 Omicron variant is rampantly spreading across the
globe. We assessed the pathogenicity and immune response generated by BA. 1.1 sub …
globe. We assessed the pathogenicity and immune response generated by BA. 1.1 sub …